Association of pregnancies with risk of multiple sclerosis.
Association of pregnancies with risk of multiple sclerosis.
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DOI：
10.1177/13524585221080542
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
文献类型：
--
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妊娠对多发性硬化症（MS）的病程有影响，但其与MS风险的关系尚不清楚。确定妊娠和妇科诊断与MS风险的关系。在这项回顾性病例对照研究中，我们评估了诊断前5年内患有MS（n = 5720）、克罗恩病（n = 6280）或银屑病（n = 40，555）的女性与没有这些自身免疫性疾病的女性（n = 26，729）之间妇科国际疾病分类第10版（ICD-10）代码记录率的差异。与无自身免疫性疾病的女性相比，MS女性记录的28个ICD-10编码频率较低，其中18个与妊娠相关。调整怀孕后，所有与怀孕无关的代码仍然与MS呈负相关。在敏感性分析中，排除了诊断前可能发生脱髓鞘事件的女性，所有相关性都更明显。与银屑病女性相比，大多数相关性都可以得到证实;与克罗恩病女性相比，情况并非如此。我们的研究结果为妊娠对MS风险的可能保护作用提供了证据，可能独立于或除了先前提出的反向因果关系。妇科疾病与疾病风险的负相关性需要进一步调查。不同的自身免疫性疾病可能有相同的关联。
Pregnancies have an impact on the disease course of multiple sclerosis (MS), but their relationship with MS risk is yet unclear. To determine the relationships of pregnancies and gynecological diagnoses with MS risk. In this retrospective case–control study, we assessed differences in gynecological International Classification of Diseases, 10th Revision (ICD-10) code recording rates between women with MS (n = 5720), Crohn’s disease (n = 6280), or psoriasis (n = 40,555) and women without these autoimmune diseases (n = 26,729) in the 5 years before diagnosis. Twenty-eight ICD-10 codes were recorded less frequently for women with MS as compared to women without autoimmune disease, 18 of which are pregnancy-related. After adjustment for pregnancies, all codes unrelated to pregnancies were still negatively associated with MS. In a sensitivity analysis excluding women with evidence for possible demyelinating events before diagnosis, all associations were more pronounced. In comparison to women with psoriasis, most associations could be confirmed; that was not true in comparison to women with Crohn’s disease. Our findings provide evidence for a possible protective effect of pregnancies on MS risk likely independent of or in addition to a previously suggested reversed causality. The negative associations of gynecological disorders with disease risk need further investigation. The associations might be shared by different autoimmune diseases.
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影响因子：
30.8
作者：
Ellinghaus D;Jostins L;Spain SL;Cortes A;Bethune J;Han B;Park YR;Raychaudhuri S;Pouget JG;Hübenthal M;Folseraas T;Wang Y;Esko T;Metspalu A;Westra HJ;Franke L;Pers TH;Weersma RK;Collij V;D'Amato M;Halfvarson J;Jensen AB;Lieb W;Degenhardt F;Forstner AJ;Hofmann A;International IBD Genetics Consortium (IIBDGC);International Genetics of Ankylosing Spondylitis Consortium (IGAS);International PSC Study Group (IPSCSG);Genetic Analysis of Psoriasis Consortium (GAPC);Psoriasis Association Genetics Extension (PAGE);Schreiber S;Mrowietz U;Juran BD;Lazaridis KN;Brunak S;Dale AM;Trembath RC;Weidinger S;Weichenthal M;Ellinghaus E;Elder JT;Barker JN;Andreassen OA;McGovern DP;Karlsen TH;Barrett JC;Parkes M;Brown MA;Franke A
通讯作者：
Franke A
影响因子：
2.7
作者：
FIRTH, D
通讯作者：
FIRTH, D
影响因子：
2
作者：
Heinze, G;Schemper, M
通讯作者：
Schemper, M
影响因子：
9.9
作者：
Ponsonby, A. -L.;Lucas, R. M.;Dwyer, T.
通讯作者：
Dwyer, T.
影响因子：
--
作者：
Murase, JE;Chan, KK;Weinstein, GD
通讯作者：
Weinstein, GD