The Warburg Effect: How Does it Benefit Cancer Cells?
The Warburg Effect: How Does it Benefit Cancer Cells?
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DOI：
10.1016/j.tibs.2015.12.001
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发表时间：
2016-03
影响因子：
13.8
通讯作者：
Locasale JW
中科院分区：
文献类型：
--
作者：
Liberti MV;Locasale JW
癌细胞重新连接它们的新陈代谢来促进生长、存活、增殖和长期维持。这种代谢改变的共同特征是葡萄糖摄取增加和葡萄糖发酵成乳酸。这种现象即使在线粒体功能完全正常的情况下也能观察到，并被称为Warburg效应。沃伯格效应已经被记录了90多年，在过去的10年里，成千上万的论文报道了它的原因或功能，并进行了广泛的研究。尽管有这种强烈的兴趣，华宝效应的作用仍然不清楚。在这里，我们分析了几种提出的瓦尔伯格效应的生物学解释，强调了它们的基本原理，并讨论了它们的争议。
Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and together is known as the Warburg Effect. The Warburg Effect has been documented for over 90 years and extensively studied over the past 10 years with thousands of papers reporting to have established either its causes or its functions. Despite this intense interest, the function of the Warburg Effect remains unclear. Here, we analyze several proposed biological explanations for the Warburg Effect, emphasize their rationale, and discuss their controversies.