Global oncofertility index-data gap slows progress.
Global oncofertility index-data gap slows progress.
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全球肿瘤生育指数数据差距减缓了进展。
DOI：
10.1093/biolre/iox051
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发表时间：
2017
影响因子：
3.6
通讯作者：
Woodruff,TeresaK
中科院分区：
文献类型：
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作者：
deRoo,SaskiaF;Rashedi,AlexandraS;Beerendonk,CatharinaCM;Anazodo,Antoinette;deMan,AnneMarie;Nelen,WillianneLDM;Woodruff,TeresaK
由于早期诊断和靶向化疗和生物治疗的扩大，全球儿童和青年癌症幸存者的数量正在增加。因此，与癌症相关的不孕不育和生殖激素的丧失是男性和女性幸存者日益关注的问题。我们试图估计在癌症生育实践国家的生殖损失，并制定全球癌症生育指数（OFI）。这样就可以对问题的紧急程度进行核算，并提供生育率下降的国家比较，这些比较根据各国或区域的流行率和/或诊断频率和治疗变量而有所不同。虽然这个目标值得称赞，但由于缺乏计算这种有意义的指数所需的信息，这样的指数是无法实现的。如果没有这一指标，我们将无法评估如何解决对癌症的关注，以及可以从随着时间的推移改进这一指数的国家吸取什么教训。
The number of pediatric and young adult cancer survivors is increasing globally due to earlier diagnostics and expansion of targeted chemo- and biological-based therapeutics. As a consequence, cancer-related infertility and reproductive hormone loss is of increasing concern for both male and female survivors. We attempted to estimate the reproductive loss in oncofertility-practicing countries and to develop a global oncofertility index (OFI). This would allow an accounting of the level of urgency of the issue and would provide national comparisons of fertility loss, which differ based on the prevalence and/or diagnosis frequency and treatment variables by countries or region. While the goal is laudable, an index such as this is unachievable due to the lack of the kind of information that would be necessary to calculate such a meaningful index. Without this metric, we will be unable to assess how oncofertility concerns are being addressed and what lessons can be learned from countries that improve such an index over time.