Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced
Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced
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DOI：
10.1038/sj.gene.6364120
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发表时间：
2004-09-01
影响因子：
5
通讯作者：
Yoshie, H
中科院分区：
文献类型：
--
作者：
Galicia, JC;Tai, H;Yoshie, H
我们研究了最近发现的 IL6R 多态性与可溶性 IL-6 受体 (sIL-6R) 血清水平的关联。 sIL-6R 是通过膜结合受体 (IL-6Rα) 脱落或选择性 mRNA 剪接产生的。总共对 115 名健康志愿者进行了基因分型，其中 70 名志愿者进行了 sIL-6R 水平分析。使用PCR/RFLP方法，选择两个重要的多态性位点进行基因分型：外显子9中的48892A/C(D358A)和启动子区域中的-183G/A。在外显子 9 中，C 等位基因携带者具有较高的 sIL-6R 水平（P
We have investigated the association of the recently identified IL6R polymorphisms with the serum levels of soluble IL-6 receptor (sIL-6R). sIL-6R is generated by shedding of the membrane-bound receptor (IL-6Ralpha) or alternative mRNA splicing. In total, 115 healthy volunteers were genotyped, with 70 of them analyzed for sIL-6R levels. Using the PCR/RFLP methods, two important polymorphic sites were selected for genotyping: the 48892A/C (D358A) in exon 9 and the - 183G/A in the promoter region. In exon 9, C allele carriers had higher sIL-6R level (P