The hamster as an animal model for eastern equine encephalitis - and its use in studies of virus entrance into the brain
The hamster as an animal model for eastern equine encephalitis - and its use in studies of virus entrance into the brain
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DOI：
10.1086/383246
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发表时间：
2004-06-01
影响因子：
6.4
通讯作者：
Weaver, SC
中科院分区：
文献类型：
--
作者：
Paessler, S;Aguilar, P;Weaver, SC
东部马脑炎病毒（EEEV）在美国产生最严重的人类虫媒病毒疾病，死亡率为30%-70%。在致命的人类东部马脑炎中，与大脑中的微血管炎相关的血管炎占主导地位，并且在疾病的晚期阶段可以检测到神经元细胞死亡。我们描述了使用金黄地鼠研究EEEV引起的急性血管炎和脑炎。在仓鼠中，EEEV在内脏器官中复制，产生病毒血症，并穿透大脑。仓鼠脑中的病理表现和抗原分布与人类EEEV病例中描述的相似。
Eastern equine encephalitis virus ( EEEV) produces the most severe human arboviral diseases in the United States, with mortality rates of 30%-70%. Vasculitis associated with microhemorrhages in the brain dominates the pathological picture in fatal human eastern equine encephalitis, and neuronal cell death is detectable during the late stage of the disease. We describe use of the golden hamster to study EEEV-induced acute vasculitis and encephalitis. In hamsters, EEEV replicates in visceral organs, produces viremia, and penetrates the brain. The pathological manifestations and antigen distribution in the brain of a hamster are similar to those described in human cases of EEEV.