Designing hydrogel adhesives for corneal wound repair
Designing hydrogel adhesives for corneal wound repair
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DOI：
10.1016/j.biomaterials.2007.08.041
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发表时间：
2007-12-01
期刊：
影响因子：
14
通讯作者：
Grinstaff, Mark W.
中科院分区：
文献类型：
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作者：
Grinstaff, Mark W.
如今，角膜伤口是用尼龙缝线修复的。然而，存在许多与缝合角膜相关的并发症，因此人们对在角膜伤口修复中替代或补充缝线的粘合剂感兴趣。我们正在设计和评估由树枝状聚合物（单一分子量和高度支化的聚合物）制备的角膜粘合剂。我们探索了两种形成这些眼部粘合剂的策略。第一个涉及光交联反应，第二个使用肽连接反应将各个树枝状聚合物偶联在一起形成粘合剂。这些粘合剂成功用于修复角膜穿孔、闭合 LASIK 手术中产生的角膜瓣以及固定角膜移植物。 (C) 2007 Elsevier Ltd. 保留所有权利。
Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers - single molecular weight and highly branched polymers. We have explored two strategies to form these ocular adhesives. The first involves a photocrosslinking reaction and the second uses a peptide ligation reaction to couple the individual dendrimers together to form the adhesive. These adhesives were successfully used to repair corneal perforations, close he flap produced in a LASIK procedure, and secure a corneal transplant. (C) 2007 Elsevier Ltd. All rights reserved.