The Mechanisms Underlying the Beneficial Effects of Stem Cell-Derived Exosomes in Repairing Ischemic Tissue Injury
The Mechanisms Underlying the Beneficial Effects of Stem Cell-Derived Exosomes in Repairing Ischemic Tissue Injury
复制标题
干细胞源性外泌体修复缺血性组织损伤有益作用的机制
DOI：
10.1007/s12265-022-10263-8
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发表时间：
2022
影响因子：
3.4
通讯作者：
Yangxin Li
中科院分区：
文献类型：
--
作者：
Yu Zhang;Lijuan Jiao;Lin Lu;Chengjie Wu;Junchu Tu;Yujie Li;Yanli Wang;Fengzhi Ding;Wei Luo;Wenjie Chen;Zhenya Shen;Yao-Hua Song;Yangxin Li
缺血性疾病是威胁生命的疾病，随着人们生活方式的改变，其发病率也随之增加。药物和手术干预提供的益处有限，干细胞疗法已成为治疗缺血性疾病的潜在方法。干细胞分泌的外泌体由于不引发免疫反应，可作为药物载体而受到更多关注。外泌体携带的非编码RNA（ncRNA）在介导外泌体的有益作用方面起着关键作用，当与纳米材料结合以提高其保留时间时，可以进一步增强这种作用。本文综述了ncRNA的下游靶分子和信号通路，并总结了一些用于包裹exosomes和促进缺血组织修复的纳米材料的最新进展。我们强调了来自亲本细胞的外泌体的印记，并讨论了炎症体途径如何成为缺血性疾病新疗法的靶点。
Ischemic diseases are life-threatening, and the incidence increases as people’s lifestyles change. Medications and surgical intervention offer limited benefit, and stem cell therapy has emerged as a potential approach for treating ischemic diseases. The exosomes secreted by stem cells have attracted more attention because they do not trigger the immune response and can be used as drug carriers. The non-coding RNA (ncRNA) carried by exosomes plays a key role in mediating exosome’s beneficial effect, which can be further enhanced when combined with nanomaterials to improve its retention time. Here, we review the downstream target molecules and signal pathways of ncRNA and summarize recent advances of some nanomaterials used to encapsulate exosomes and promote ischemic tissue repair. We highlight the imprinting of exosomes from parent cells and discuss how the inflammasome pathway may be targeted for the development of novel therapy for ischemic diseases.