CONSTRUCTION OF MULTILOCUS GENETIC-LINKAGE MAPS IN HUMANS
CONSTRUCTION OF MULTILOCUS GENETIC-LINKAGE MAPS IN HUMANS
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DOI：
10.1073/pnas.84.8.2363
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发表时间：
1987-04-01
影响因子：
11.1
通讯作者：
GREEN, P
中科院分区：
文献类型：
--
作者：
LANDER, ES;GREEN, P
同时利用多个基因座的信息构建人类遗传连锁图是最精确的方法。这种多位点连锁分析的传统方法通常在计算上是禁止的，即使使用超级计算机。这个问题已经获得了实际的重要性，因为目前的国际合作，旨在构建一个完整的人类连锁图谱的DNA标记，通过研究三代系谱。我们在这里描述了几种替代算法构建人类连锁图谱给定一个指定的基因顺序。其中一种方法可以在几分钟内为这样的三代系谱中的几十个DNA标记构建最大似然多位点连锁图。
Human genetic linkage maps are most accurately constructed by using information from many loci simultaneously. Traditional methods for such multilocus linkage analysis are computationally prohibitive in general, even with supercomputers. The problem has acquired practical importance because of the current international collaboration aimed at constructing a complete human linkage map of DNA markers through the study of three-generation pedigrees. We described here several alternative algorithms for constructing human linkage maps given a specified gene order. One method allows maximum-likelihood multilocus linkage maps for dozens of DNA markers in such three-generation pedigrees to be constructed in minutes.