Cerebral and systemic hemodynamic changes during cognitive and motor activation paradigms
Cerebral and systemic hemodynamic changes during cognitive and motor activation paradigms
复制标题
DOI：
10.1152/ajpregu.00837.2004
复制
发表时间：
2005-06-01
影响因子：
2.8
通讯作者：
Potter, JF
中科院分区：
文献类型：
--
作者：
Moody, M;Panerai, RB;Potter, JF
对大脑的认知和/或感觉运动刺激导致脑血流量增加，这通常与代谢需求增加有关。我们测试了这一假设，即动脉血压(ABP)和动脉二氧化碳分压(PCO2)的变化也发生在旨在诱导大脑半球偏侧化的大脑激活方案中，除了大脑刺激范式通常假设的代谢驱动的变化外，还会导致压力自动调节反应。对15名右撇子健康受试者(年龄21-43岁)进行脑血流速度[CBFV；双侧大脑中动脉(MCA)]、动脉压(ABP)、心电图和呼气末二氧化碳分压(PETCO2)的连续记录。衍生变量包括心率、脑血管阻力、临界闭合压、阻力面积乘积和左右大脑中动脉记录的差异(CBFVR-L)。对于任一范式，重复呈现10个激活任务都没有发现CBFVR-L差异的适应性。在词汇生成任务的激活过程中，CBFV变化9.0+/-3.7%(右侧大脑中动脉，P=0.0007)和12.3+/-7.6%(左侧大脑中动脉，P=0.0007)，动脉压变化7.7+/-6.0毫米汞柱(P=0.0007)，心率7.1+/-5.3次/分钟(P=0.0008)，PETCO2-2.32+/-2.23Torr(P=0.002)。对于拼图范式，CBFV13.9+/-6.6%(右侧大脑中动脉，P=0.0007)和11.5+/-6.2%(左侧大脑中动脉，P=0.0007)，动脉压7.1+/-8.4毫米汞柱(P=0.0054)，心率7.9+/-4.6次/分钟(P=0.0008)，PETCO2-2.42+/-2.59Torr(P=0.001)。词汇范式导致的左脑优势大于右脑优势(P=0.004)。我们的结论是，在脑激活方案期间，ABP和PETCO2水平发生了显著变化，这有助于CBFV的诱发变化。除了代谢需求增加引起的血流动力学变化外，还可以观察到压力自动调节反应。二氧化碳分压和心率的同时变化增加了反应的复杂性，表明需要更详细的建模和更好地理解大脑激活范例。
Cognitive and/or sensorimotor stimulations of the brain induce increases in cerebral blood flow that are usually associated with increased metabolic demand. We tested the hypothesis that changes in arterial blood pressure (ABP) and arterial PCO2 also take place during brain activation protocols designed to induce hemispheric lateralization, leading to a pressure-autoregulatory response in addition to the metabolic-driven changes usually assumed by brain stimulation paradigms. Continuous recordings of cerebral blood flow velocity [CBFV; bilateral, middle cerebral artery (MCA)], ABP, ECG, and end-tidal PCO2 (PETCO2) were performed in 15 right-handed healthy subjects ( aged 21-43 yr), in the seated position, at rest and during 10 repeated presentations of a word generation and a constructional puzzle paradigm that are known to induce differential cortical activation. Derived variables included heart rate, cerebrovascular resistance, critical closing pressure, resistance area product, and the difference between the right and left MCA recordings (CBFVR-L). No adaptation of the CBFVR-L difference was detected for the repeated presentation of 10 activation tasks, for either paradigm. During activation with the word generation tasks, CBFV changed by (mean +/- SD) 9.0 +/- 3.7% (right MCA, P = 0.0007) and by 12.3 +/- 7.6% (left MCA, P = 0.0007), ABP by 7.7 +/- 6.0 mmHg (P = 0.0007), heart rate by 7.1 +/- 5.3 beats/min (P = 0.0008), and PETCO2 by -2.32 +/- 2.23 Torr (P = 0.002). For the puzzle paradigm, CBFV changed by 13.9 +/- 6.6% (right MCA, P = 0.0007) and by 11.5 +/- 6.2% (left MCA, P = 0.0007), ABP by 7.1 +/- 8.4 mmHg (P = 0.0054), heart rate by 7.9 +/- 4.6 beats/min (P = 0.0008), and PETCO2 by -2.42 +/- 2.59 Torr (P = 0.001). The word paradigm led to greater left hemispheric dominance than the right hemispheric dominance observed with the puzzle paradigm (P = 0.004). We concluded that significant changes in ABP and PETCO2 levels occur during brain activation protocols, and these contribute to the evoked change in CBFV. A pressure-autoregulatory response can be observed in addition to the hemodynamic changes induced by increases in metabolic demand. Simultaneous changes in PCO2 and heart rate add to the complexity of the response, indicating the need for more detailed modeling and better understanding of brain activation paradigms.