The London Cord Blood Bank: analysis of banking and transplantation outcome
The London Cord Blood Bank: analysis of banking and transplantation outcome
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DOI：
10.1111/j.1365-2141.2004.04923.x
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发表时间：
2004-05-01
影响因子：
6.5
通讯作者：
Navarrete, CV
中科院分区：
文献类型：
--
作者：
Davey, S;Armitage, S;Navarrete, CV
脐带血储存在伦敦脐带血库（n = 5500），包括59个单位移植到高风险和异质性组的患者，进行了分析。44例患者的移植结局数据可用，中位临床随访时间为14个月（范围3-44个月）。超过40%的采集单位为少数民族来源，中位体积为79 ml（范围40-240 ml），中位总有核细胞（TNC）计数为11.9 x 10（9）/l（范围10.0-24.8 x 10（9）/l）。患者的平均体重为28 kg（范围5-80 kg），中位年龄为8岁（范围0.7-40岁）。输注的有核细胞中位数为4 × 10（7）/kg（范围1.10-16 × 10（7）/kg）。在33例（74+/-%）患者中观察到0.5 x 10（9）/l的神经元植入，平均时间为28天（范围11-60）。第100天时急性移植物抗宿主病（II级）的Kaplan-Meier估计值为37 +/- 7%，27例（62%）患者为I级或不存在。2年总生存率和无病生存率分别为49 +/- 8%和41 +/-8%。移植后2年，接受6/6或5/6 HLA配型单位的患者的存活率分别为69%和54%。感染是这些患者移植相关死亡的主要原因。
Cord blood units (n = 5500) stored at the London Cord Blood Bank, including 59 units transplanted into a high risk and heterogeneous group of patients, were analysed. Transplant outcome data was available for 44 patients with a median clinical follow-up of 14 months (range 3-44 months). Over 40% of the collected units were of ethnic minority origin with a median volume of 79 ml (range 40-240 ml) and a median total nucleated cell (TNC) count of 11.9 x 10(9)/l (range 10.0-24.8 x 10(9)/l). The average patient's weight was 28 kg (range 5-80 kg) and the median age was 8 years (range 0.7-40 years). The median number of nucleated cells infused was 4 x 10(7)/kg (range 1.10-16 x 10(7)/kg). Neutrophil engraftment of 0.5 x 10(9)/l was observed in 33 (74+/-%) patients with an average time of 28 days (range 11-60). The Kaplan-Meier estimate of acute graft-versus-host disease (grade II >) at day 100 was 37 +/- 7% and in 27 (62%) patients, it was grade I or absent. The overall survival and disease-free survival at 2 years was 49 +/- 8% and 41 +/- 8%, respectively. Two years after transplantation the survival rate was 69% and 54% for patients receiving a 6/6 or 5/6 HLA matched units, respectively. Infection was the main cause of transplanted related mortality in these patients.