Androgen receptor in human health: a potential therapeutic target.
Androgen receptor in human health: a potential therapeutic target.
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DOI：
10.2174/138945012804545579
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发表时间：
2012-11
影响因子：
3.2
通讯作者：
Hifzur R Siddique;S. Nanda;A. Parray;M. Saleem
中科院分区：
文献类型：
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作者：
Hifzur R Siddique;S. Nanda;A. Parray;M. Saleem
雄激素是大多数疾病中雄激素受体（AR）激活的关键，然而，在侵袭型人类恶性肿瘤中也发现了雄激素非依赖性AR激活。目前正在加紧寻找AR抑制剂，以治愈AR依赖性疾病。除了靶向AR信号通路的各种组分之外，直接靶向AR的化合物正在进行临床前和临床研究。各种体外和临床前动物研究表明，不同的天然化合物具有对抗AR的潜力。已经发现一些天然化合物对AR是非常有效的，而不管不同的给药途径，即口服、腹膜内和静脉内。这篇简短的综述总结了用不同的天然药物进行的研究，以确定它们对AR信号的药理学效用。
Androgen is a key for the activation of Androgen Receptor (AR) in most of the disease conditions, however androgen-independent activation of AR is also found in aggressive type human malignancies. An intense search for the inhibitors of AR is underway to cure AR-dependent diseases. In addition to targeting various components of AR signaling pathway, compounds which directly target AR are under preclinical and clinical investigation. Various In vitro and preclinical animal studies suggest that different natural compounds have potential to act against AR. Some natural compounds have been found to be pharmacologically effective against AR irrespective of varying routs of administration viz; oral, intra-peritoneal and intravenous. This mini-review summarizes the studies conducted with different natural agents in determining their pharmacological utility against AR signaling.