Very High-Frequency Oscillations (Over 1000 Hz) of Somatosensory-Evoked Potentials Directly Recorded From the Human Brain
Very High-Frequency Oscillations (Over 1000 Hz) of Somatosensory-Evoked Potentials Directly Recorded From the Human Brain
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DOI：
10.1097/wnp.0b013e3181c298c9
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发表时间：
2009-12-01
影响因子：
2.4
通讯作者：
Inoue, Yushi
中科院分区：
文献类型：
--
作者：
Sakura, Yuji;Terada, Kiyohito;Inoue, Yushi
本研究的目的是记录与硬脑膜下电极体感诱发电位相关的高频振荡（HFOs），并探讨其产生机制和临床意义。对6例接受长期硬膜下电极监测的患者进行了研究。刺激正中神经后直接从硬膜下电极记录体感诱发电位。常规体感诱发电位带通滤波器为10 ~ 10,000 Hz， HFO为500 ~ 10,000 Hz。记录了三种HFO类型。第一个分量为早期HFO (407 ~ 926 Hz)，发生在N20峰之前。第二部分为后期HFO (408 ~ 909 Hz)，发生在N20峰之后。此外，还记录了一个新的分量，其范围从1,235到2,632 Hz，该分量被称为very HFO。早期和晚期的HFO分布在以初级运动区和初级感觉区为中心的相对较宽的区域，而大部分HFO集中在初级感觉区周围。在本研究中，至少可以鉴定出HFO的三种成分。只有非常高的HFO定位在初级感觉区周围，这表明非常高的HFO可能提供了识别中央沟的有效方法。
The aims of this study were to record high-frequency oscillations (HFOs) associated with somatosensory-evoked potentials from subdural electrodes and to investigate their generators and clinical significance. Six patients who underwent long-term subdural electrode monitoring were studied. Somatosensory-evoked potentials were recorded directly from the subdural electrode after stimulation of the median nerve. Bandpass filter was 10 to 10,000 Hz for conventional somatosensory-evoked potential and 500 to 10,000 Hz for HFO. Three types of HFO were recorded. The first component was early HFO (407-926 Hz), which occurred before N20 peak. The second component was late HFO (408-909 Hz), which occurred after N20 peak. In addition, a novel component was recorded with a range from 1,235 to 2,632 Hz, and this component was termed very HFO. Early and late HFOs were recorded from relatively wide areas centering around the primary motor and primary sensory areas, whereas very HFO was localized around the primary sensory areas. In this study, at least three components of HFO could be identified. Only very HFO was localized around primary sensory areas, suggesting a possibility that very HFO may provide an effective method of identifying the central sulcus.