Using Hyperpolarized (129)Xe MRI to Quantify the Pulmonary Ventilation Distribution.
Using Hyperpolarized (129)Xe MRI to Quantify the Pulmonary Ventilation Distribution.
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DOI：
10.1016/j.acra.2016.07.014
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发表时间：
2016-12
影响因子：
4.8
通讯作者：
Huang YT
中科院分区：
文献类型：
--
作者：
He M;Driehuys B;Que LG;Huang YT
肺量测定法无法检测通气异质性。或者，肺通气可以使用吸入129 μ M MRI进行三维成像。迄今为止，这些图像主要是基于通风缺陷进行量化的。在这里，我们介绍了一种强大的手段来转换129个MRI扫描，使潜在的通气分布及其异质性可以量化。对12例年轻（24.7±5.2岁）和10例老年（62.2±7.2岁）健康人以及9例年轻（25.9±6.4岁）和10例老年（63.2±6.1岁）哮喘患者进行了定量129 μ m通气MRI。年轻的健康人群被用来建立一个参考通气分布和阈值为6强度箱。这些用于显示和量化通气缺陷（VDR）、低通气（LVR）和高通气（HVR）区域。年轻受试者的通气量分布大致为高斯分布，平均值和SD为0.52±0.18，导致VDR=2.1± 1.3%，LVR=15.6±5.4%，HVR=17.4± 3.1%。老年健康志愿者呈现显著右偏分布（0.46±0.20，p=0.034），导致VDR（7.0± 4.8%，p=0.008）和LVR（24.5± 11.5%，p=0.025）显著增加。在哮喘患者中，老年人群的VDR和LVR增加，HVR显著降低（13.5±4.6% vs 18.9± 4.5%，p=0.009）。定量129 <$MRI还显示了两名FEV 1正常的哮喘患者对沙丁胺醇反应的不同通气分布模式。定量129 MRI提供了一种稳健和客观的方法来显示和量化肺通气分布，即使是在呼吸量测定法无法识别的气道功能障碍受试者中。
Ventilation heterogeneity is impossible to detect with spirometry. Alternatively, pulmonary ventilation can be imaged 3-dimensionally using inhaled 129Xe MRI. To date such images have been quantified primarily based on ventilation defects. Here, we introduce a robust means to transform 129Xe MRI scans such that the underlying ventilation distribution and its heterogeneity can be quantified. Quantitative 129Xe ventilation MRI was conducted in 12 younger (24.7±5.2 yrs), and 10 older (62.2±7.2 yrs) healthy individuals, as well as 9 younger (25.9±6.4 yrs) and 10 older (63.2±6.1 yrs) asthmatics. The younger healthy population was used to establish a reference ventilation distribution and thresholds for 6 intensity bins. These were used to display and quantify regions of ventilation defect (VDR), low ventilation (LVR) and high ventilation (HVR). The ventilation distribution in young subjects was roughly Gaussian with a mean and SD of 0.52±0.18, resulting in VDR=2.1±1.3%, LVR=15.6±5.4% and HVR=17.4±3.1%. Older healthy volunteers exhibited a significantly right-skewed distribution (0.46±0.20, p=0.034), resulting in significantly increased VDR (7.0±4.8%, p=0.008) and LVR (24.5±11.5%, p=0.025). In the asthmatics, VDR and LVR increased in the older population, and HVR was significantly reduced (13.5±4.6% vs 18.9±4.5%, p=0.009). Quantitative 129Xe MRI also revealed different ventilation distribution patterns in response to albuterol in two asthmatics with normal FEV1. Quantitative 129Xe MRI provides a robust and objective means to display and quantify the pulmonary ventilation distribution, even in subjects who have airway function impairment not appreciated by spirometry.