Retinal stimuli can be restored after autologous transplant of retinal pigment epithelium and choroid in pigment epithelium tears
Retinal stimuli can be restored after autologous transplant of retinal pigment epithelium and choroid in pigment epithelium tears
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DOI：
10.1111/j.1755-3768.2011.02143.x
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发表时间：
2011-09-01
影响因子：
3.4
通讯作者：
Kirchhof, Bernd
中科院分区：
文献类型：
--
作者：
Caramoy, Albert;Fauser, Sascha;Kirchhof, Bernd
目的：评价老年性黄斑变性（AMD）并发视网膜色素上皮（RPE）撕裂后自体移植视网膜色素上皮（RPE）及脉络膜的功能和解剖学结果。方法：回顾性分析9例患者9只眼的资料。检查包括荧光素和吲哚菁绿血管造影、眼底自身荧光成像、光学相干断层扫描、显微镜检查和视力（远、读能力）测定。记录术中及术后并发症的相关数据。平均随访时间18个月（4个月~ 5年）。结果：术后3 / 9眼远视力改善或保持稳定（+/- 3线），3 / 9眼近视力改善。4眼术后末次随访视力下降主要是由于术后并发症，即增生性玻璃体视网膜病变所致的视网膜脱离、视网膜动脉闭塞、移植物皱缩及纤维化。在一个病例中，视网膜刺激在暗斑上恢复，如显微镜所见。结论：自体RPE和脉络膜移植是治疗RPE撕裂的有效方法。在某些情况下，视网膜刺激可以恢复。许多手术内和术后并发症损害了功能预后和预后。
Purpose: To evaluate the functional and anatomical outcome of patients undergoing autologous transplant of retinal pigment epithelium (RPE) and choroid after RPE tear secondary to age-related macular degeneration (AMD).Methods: Data from nine eyes of nine patients were analysed retrospectively. Examinations included fluorescein and indocyanine green angiography, fundus autofluorescence imaging, optical coherence tomography, microperimetry and determination of visual acuity (far and reading ability). Data regarding intraoperative and postoperative complications were recorded. Mean follow-up time was 18 months (range 4 months to 5 years).Results: After surgery, far visual acuity improved or remained stable (+/- 3 lines) in three of nine eyes and for the near visual acuity in three of nine eyes. Visual acuity decreased postoperatively at the last follow-up in four eyes mainly because of postoperative complications, i.e. retinal detachment due to proliferative vitreoretinopathy, retinal artery occlusion, pucker and fibrosis of the graft. In one case, retinal stimuli were restored over the scotoma as seen in microperimetry.Conclusion: Autologous transplant of RPE and choroid is a therapy option for RPE tears. Retinal stimuli can be restored in selected cases. Numerous intra- and postoperative complications compromise the functional prognosis and outcome.