A new thermal stimulation method for human psychophysical studies: Pain intensity clamping
A new thermal stimulation method for human psychophysical studies: Pain intensity clamping
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DOI：
10.1016/j.jneumeth.2010.02.001
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发表时间：
2010-04-30
影响因子：
3
通讯作者：
Mauderli, Andre P.
中科院分区：
文献类型：
--
作者：
Wong, Fong;Vierck, Charles J.;Mauderli, Andre P.
介绍了一种用于测试人类受试者在长时间热刺激过程中疼痛敏感性变化的方法。它使用基于Peltier设备的热电极来产生热接触刺激，使用电子视觉模拟量表来连续记录疼痛强度，并使用一个系统来控制选定的刺激参数（温度或脉冲时间）作为疼痛强度等级的函数。被调制以将疼痛强度钳制在期望的设定点附近的刺激参数用作响应变量，并用于推断疼痛敏感性。该方法的优点是，它自动找到激发预定疼痛强度的刺激幅度，而不管受试者是多么敏感或不敏感，并且它允许延长刺激，因为它不允许疼痛强度由于渐进致敏而升级到不可接受的水平。受试者对实验效果设盲，因为无论致敏或药物干预如何，平均疼痛强度保持恒定。(C)2010爱思唯尔有限公司版权所有。
A method for testing changes in pain sensitivity of human subjects over the course of prolonged thermal stimulation is introduced. It uses a Peltier-device-based thermode to generate a thermal contact stimulus, an electronic visual analog scale to continuously record the pain intensity and a system that controls selected stimulus parameters (temperature or pulse timing) as a function of the pain intensity rating. The stimulus parameter that is modulated to clamp pain intensity near a desired setpoint serves as the response variable and is used to infer pain sensitivity. Advantages of the method are that it automatically finds the stimulus magnitude that elicits predetermined pain intensity, regardless of how sensitive or insensitive the subject is, and it allows prolonged stimulation, because it does not allow pain intensity to escalate to unacceptable levels due to progressive sensitization. The subject is blinded regarding experimental effects because average pain intensity remains constant regardless of sensitization or pharmacological interventions. (C) 2010 Elsevier B.V. All rights reserved.