Two cases of eruptive pseudoangiomatosis induced by mosquito bites
Two cases of eruptive pseudoangiomatosis induced by mosquito bites
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蚊虫叮咬致发疹性假性血管瘤病二例
DOI：
10.1111/j.1346-8138.2010.01144.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
H. Yokozeki
中科院分区：
文献类型：
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作者：
K. Oka;N. Ohtaki;S. Kasai;K. Takayama;H. Yokozeki
发疹性假血管瘤病是一种皮疹，其特征是在暴露的身体区域出现粟粒大小的红斑伴贫血晕。昆虫叮咬，特别是蚊子叮咬，已被报道为发疹性假血管瘤病的原因之一。我们经历了两例发疹性假血管瘤病和皮疹被认为是对面部和上肢的两名妇女，年龄分别为48岁和77岁。 这两个病例同意实验性地被尖音库蚊和白纹伊蚊叮咬，以确定这些蚊子是否可以实验性地诱发发疹性假血管瘤病。我们的结果表明，C. pipiens蚊虫叮咬后，叮咬部位出现红斑，30 min后在红斑周围形成贫血晕，成功再现发疹性假血管瘤病。 红斑持续一周以上，未伴有任何瘙痒。名为.在白纹症患者中，我们能够重现较轻的发疹性假血管瘤病皮疹：在病例1中，较小的发疹性斑点伴不明确的晕圈，在1周内消失;在病例2中，立即反应包括风团和红斑，但不是发疹性假血管瘤病。 我们证明了发疹性假血管瘤病是在通常对昆虫叮咬没有任何立即或延迟反应的个体中表现出的反应;典型的发疹性假血管瘤病发疹是由C.蚊子叮咬。然而，导致发疹性假血管瘤病的表现的机制仍然是未知的。
Eruptive pseudoangiomatosis is a skin eruption characterized by millet‐sized erythema with an anemic halo appearing on exposed body areas. Insect bites, particularly mosquito bites, have been reported as one of the causes of eruptive pseudoangiomatosis. We experienced two cases of eruptive pseudoangiomatosis and the eruption was seen on the face and upper extremities of two women aged 48 and 77 years old. The two cases consented to be experimentally bitten by Culex pipiens mosquitoes and Aedes albopictus to determine if eruptive pseudoangiomatosis could be experimentally elicited by these mosquitoes. Our results showed that several minutes after a C. pipiens mosquito bite, an erythematous spot appeared on the bite site, followed by the formation of an anemic halo surrounding the erythema in 30 min; a successful reproduction of eruptive pseudoangiomatosis. The erythema lasted for more than a week and was not accompanied by any pruritus. With A. albopictus, we were able to reproduce a milder eruptive pseudoangiomatosis eruption: in case 1, a smaller erythematous spot with an ill‐defined halo which disappeared within 1 week; and in case 2, an immediate response consisting of a wheal and erythema but not eruptive pseudoangiomatosis. We demonstrated that eruptive pseudoangiomatosis was the response manifested in individuals who normally did not demonstrate any immediate or delayed reaction to insect bites; and the typical eruptive pseudoangiomatosis eruption was elicited by C. pipiens mosquito bites. However, the mechanism resulting in the manifestation of eruptive pseudoangiomatosis is still unknown.