FLOSS: flexible ordered subset analysis for linkage mapping of complex traits
FLOSS: flexible ordered subset analysis for linkage mapping of complex traits
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DOI：
10.1093/bioinformatics/btk012
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发表时间：
2006-02-15
期刊：
影响因子：
5.8
通讯作者：
Browning, BL
中科院分区：
文献类型：
--
作者：
Browning, BL
FLOSS软件包是一个灵活的有序子集分析框架。FLOSS专门设计用于Merlin连锁分析软件包，但FLOSS可用于任何连锁分析软件包，报告每个基因座和家族的NPL Z-评分。当FLOSS与Merlin连锁分析软件包一起使用时，可以使用非参数Z分数或Kong和考克斯线性等位基因共享模型LOD分数。Monte Carlo P值使用置换检验和有效的Besag-Clifford顺序停止规则计算。FLOSS也有一个灵活的工具，用于从Merlin输入文件分配家族协变量评分。FLOSS包括用户文档，并且是用Java编写的，便于移植。FLOSS源代码是有文档的，并且设计为可扩展的。
The FLOSS software package is a flexible framework for ordered subset analysis. FLOSS is specifically designed for use with the Merlin linkage analysis package, but FLOSS can be used with any linkage analysis software package that reports NPL Z-scores for each locus and family. When FLOSS is used with the Merlin linkage analysis package, one can use either non-parametric Z-scores or Kong and Cox linear allele sharing model LOD scores. Monte Carlo P-values are calculated using a permutation test with an efficient Besag-Clifford sequential stopping rule. FLOSS also has a flexible tool for assigning family covariate scores from Merlin input files. FLOSS includes user documentation and is written in Java for easy portability. The FLOSS source code is documented and designed to be extensible.