HUMAN POLYOMAVIRUS JC-VIRUS GENOME
HUMAN POLYOMAVIRUS JC-VIRUS GENOME
复制标题
DOI：
10.1128/jvi.51.2.458-469.1984
复制
发表时间：
1984-01-01
影响因子：
5.4
通讯作者：
CANNELLA, MT
中科院分区：
文献类型：
--
作者：
FRISQUE, RJ;BREAM, GL;CANNELLA, MT
人类JC病毒的完整DNA序列，由5130个核苷酸对，提出。可以推导出6种蛋白质的氨基酸序列：早期非结构蛋白，大T和小T抗原;晚期衣壳蛋白，VP 1，VP 2和VP 3;以及在晚期前导序列内编码的未知基因产物，称为SV 40中的未知蛋白。JC病毒DNA与SV 40（69%）和BK病毒（75%）基因组的同源性证实了这3种多瘤病毒的密切进化关系。在这些病毒DNA中表现出最大差异的序列发生在位于复制起点晚期的串联重复序列内。
The complete DNA sequence of the human JC virus, consisting of 5130 nucleotide pairs, is presented. The amino acid sequence of 6 proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2 and VP3: and the agnogene product encoded within the late leader sequence, called the agnoprotein in SV40. The extent of homology between JC virus DNA and the genomes of SV40 (69%) and BK virus (75%) confirmed the close evolutionary relationship of these 3 polyomaviruses. The sequences showing the greatest divergence in these viral DNA occurred within the tandem repeats located to the late side of the replication origins.