Critical periods for the effects of alcohol exposure on learning in rats.
Critical periods for the effects of alcohol exposure on learning in rats.
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DOI：
10.1037/0735-7044.115.1.138
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发表时间：
2001-02
影响因子：
1.9
通讯作者：
K. Cronise;M. Marino;T. Tran;S. Kelly
中科院分区：
文献类型：
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作者：
K. Cronise;M. Marino;T. Tran;S. Kelly
采用胎儿酒精综合征大鼠模型，研究了酒精诱导的空间导航和被动回避学习障碍的关键期。大鼠在出生前（Gestival第1-10或11-22天）或出生后（出生后第2-10天）或在所有3个阶段暴露于酒精。后代进行了测试，无论是空间导航或回避任务的青少年或成年人。作为青少年，与所有其他组相比，联合暴露组需要更长的时间来学习空间导航任务。这种影响在成年人中没有出现。被动回避性能不受影响。这些结果表明，在发展过程中长期接触酒精对空间学习有不利影响。短期暴露组之间缺乏差异意味着可能没有一个酒精暴露的关键时期，但酒精在发育过程中的不良影响可能会累积在某些行为上。
Critical periods for alcohol-induced deficits in spatial navigation and passive avoidance learning were investigated with a rat model of fetal alcohol syndrome. Rats were exposed to alcohol prenatally (Gestational Days 1-10 or 11-22) or postnatally (Postnatal Days 2-10) or throughout all 3 periods. Offspring were tested in either a spatial navigation or an avoidance task as juveniles or adults. As juveniles, the combined exposure group took longer to learn the spatial navigation task compared with all other groups. This effect was not seen in adults. Passive avoidance performance was not affected. These results suggest that long-term exposure to alcohol during development has adverse effects on spatial learning. The lack of differences in the short-term exposure groups implies that there may not be 1 critical period of alcohol exposure, but that the adverse effects of alcohol during development may be cumulative on some behaviors.