Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats.
Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats.
复制标题
在伊普林多治疗的大鼠中，单次注射安非他明可长期消耗纹状体多巴胺。
作者：
R. Fuller;S. Hemrick
与伊普哚同时治疗的大鼠单次注射安非他明，使其不能通过对羟基化代谢安非他明，导致纹状体多巴胺浓度在1周后下降。这种减少被氨苯酸拮抗，氨苯酸是一种摄取多巴胺神经元的抑制剂。安非他明对大脑多巴胺的长期消耗可能类似于安非他明卤化衍生物对大脑血清素的消耗。
A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.