Task-specific signal transmission from prefrontal cortex in visual selective attention
Task-specific signal transmission from prefrontal cortex in visual selective attention
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DOI：
10.1038/nn.2237
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发表时间：
2009-01-01
影响因子：
25
通讯作者：
Sakai, Katsuyuki
中科院分区：
文献类型：
--
作者：
Morishima, Yosuke;Akaishi, Rei;Sakai, Katsuyuki
我们的自愿行为被认为是由来自前额叶皮层的自上而下的信号控制的，前额叶皮层根据行为目标调节后额叶皮层的神经处理。然而，我们没有足够的证据证明自上而下的信号的因果关系。我们对人类前额叶皮质施加单脉冲经颅磁刺激，并测量自上而下信号的强度，以提高神经脉冲传输的效率。由刺激引起的冲动传递到不同的后部视区，这取决于受试者关注的视觉特征的域。我们还发现，脉冲传输量与注意准备水平和视觉选择注意任务的表现有关，这与前额叶自上而下信号的因果作用一致。
Our voluntary behaviors are thought to be controlled by top-down signals from the prefrontal cortex that modulate neural processing in the posterior cortices according to the behavioral goal. However, we have insufficient evidence for the causal effect of the top-down signals. We applied a single-pulse transcranial magnetic stimulation over the human prefrontal cortex and measured the strength of the top-down signals as an increase in the efficiency of neural impulse transmission. The impulse induced by the stimulation transmitted to different posterior visual areas depending on the domain of visual features to which subjects attended. We also found that the amount of impulse transmission was associated with the level of attentional preparation and the performance of visual selective-attention tasks, consistent with the causal role of prefrontal top-down signals.