THE FIBROMYALGIA SYNDROME - MUSCULOSKELETAL PATHOPHYSIOLOGY
THE FIBROMYALGIA SYNDROME - MUSCULOSKELETAL PATHOPHYSIOLOGY
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DOI：
10.1016/0049-0172(94)90030-2
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发表时间：
1994-04-01
影响因子：
5
通讯作者：
GEEL, SE
中科院分区：
文献类型：
--
作者：
GEEL, SE
纤维肌痛（FM）是一种慢性疼痛疾病，主要困扰中年女性，主要症状为弥漫性肌肉骨骼疼痛、明确的压痛点、睡眠不足和疲劳。病因和病理机制知之甚少，治疗方法基本无效。综合征的临床特点，并探讨肌肉功能障碍的发病机制的相关性。参与肌肉病理生理学作为介导症状发作的主要机制的证据并不令人信服。肌肉骨骼功能障碍可以被认为是继发于中枢异常的疼痛调制和改变睡眠生理沉淀的情绪压力在遗传易感个体。当代的证据支持强调疼痛控制、睡眠增强和调节的治疗策略。
Fibromyalgia (FM) is a chronic pain disorder that afflicts predominantly middle-aged women with cardinal symptoms of diffuse musculoskeletal pain, defined tender points, deprived sleep, and fatigue. The etiology and pathological mechanisms are poorly understood, and treatment approaches are largely ineffective. The clinical features of the syndrome are presented, and the relevance of muscle dysfunction in the etiopathogenesis of the disorder is explored. The evidence for involvement of muscle pathophysiology as a primary mechanism mediating the onset of symptoms is not compelling. Musculoskeletal dysfunction can be considered secondary to central abnormalities of pain modulation and altered sleep physiology precipitated by emotional stress in genetically predisposed individuals. Contemporary evidence favors treatment strategies that emphasize pain control, sleep enhancement, and a program of conditioning.