Salivary gland function in HIV-infected patients treated with highly active antiretroviral therapy (HAART)
Salivary gland function in HIV-infected patients treated with highly active antiretroviral therapy (HAART)
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DOI：
10.1016/j.tripleo.2005.07.021
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发表时间：
2006-09-01
影响因子：
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通讯作者：
Yeh, Chih-Ko
中科院分区：
文献类型：
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作者：
Lin, Alan L.;Johnson, Dorthea A.;Yeh, Chih-Ko
Objective.本研究旨在确定HAART是否改变HIV（+）男性的唾液口腔宿主防御。从39名健康男性和147名轻度至中度免疫功能障碍的HIV（+）患者（69名接受HAART治疗[HAART（+）]; 78名未接受HAART治疗[HAART（-）]）中收集全部唾液、腮腺唾液和下颌下/舌下唾液。唾液流速，anticandidal活动，电解质，和抗菌/抗真菌蛋白进行了测定。虽然HIV（+）组之间的CD 4（+）细胞计数没有差异，但HAART（-）的中位病毒载量是HAART（+）的15倍。对于两个HAART组，唾液酵母菌携带率和浓度是相当的，两者都显示出类似的唾液流速降低。唾液anticandidal活动没有改变。两组患者唾液成分均与对照组不同，HAART（+）组与HAART（-）组唾液中仅尿酸存在差异。HAART不会对轻度至中度免疫功能障碍的HIV（+）患者的固有唾液口腔宿主防御产生不利影响。
Objective. This study was undertaken to determine if HAART alters salivary oral host defense in HIV(+) men.Study design. Whole, parotid, and submandibular/sublingual saliva was collected from 39 healthy men and 147 HIV(+) patients with mild to moderate immune dysfunction (69 treated with HAART [HAART(+)]; 78 not treated [HAART(-)]). Salivary flow rates, anticandidal activities, electrolytes, and antimicrobial/antifungal proteins were determined.Results. While CD4(+) cell counts were not different between the HIV(+) groups, the median viral load for HAART(-) was 15 times greater than HAART(+). For both HAART groups, salivary yeast carriage rates and concentration were comparable and both showed similar reductions in salivary flow rates. Salivary anticandidal activities were not altered. Saliva composition of both HIV(+) groups was different from control, but only uric acid in parotid saliva of HAART(+) differed from HAART(-).Conclusions. HAART does not adversely affect inherent salivary oral host defense in HIV(+) patients with mild to moderate immune dysfunction.