Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
复制标题
DOI：
10.1016/j.cellbi.2006.04.002
复制
发表时间：
2006-07-01
影响因子：
3.9
通讯作者：
Jersmann, Hubertus Pa.
中科院分区：
文献类型：
--
作者：
Bignold, Leon P.;Coghlan, Brian L. D.;Jersmann, Hubertus Pa.
特奥多尔·博韦里（Theodor Boveri，1862-1915）在1914年提出了第一个癌症染色体理论，特别是在成年细胞多极有丝分裂中产生的异常数量的染色体方面。然而，早在1875年就有人描述了动物细胞中的多极有丝分裂，Hansemann（1858-1920）在1890 - 1919年的出版物中将这种机制包括在细胞中染色体数目异常并导致肿瘤形成的各种方式中。这两种理论都是在肿瘤形成的配子发生思想流行的时期构思出来的。Boveri的理论基于他的观察，即早期海胆胚胎中的一些细胞具有异常的染色体互补物，偏离了它们通常的发育路径。他的观察结果可能被当时的其他作者视为对科恩海姆癌症“胚胎细胞休止”理论的支持。汉斯曼的贡献被认为是癌症的染色体理论的原始和更重要的。(c)2006年国际细胞生物学联合会。由爱思唯尔有限公司出版。保留所有权利。
Theodor Boveri (1862-1915) is often credited with suggesting (in 1914) the first chromosomal theory of cancer, especially in terms of abnormal numbers of chromosomes arising in cells by multipolar mitoses in adult cells. However, multipolar mitoses in animal cells had been described as early as 1875, and Hansemann (1858-1920), in publications between 1890 and 1919, included this mechanism among various ways by which abnormal chromosome numbers might arise in cells and cause tumour formation. Both theories were conceived in a period when gametogenic ideas of tumour formation were current. Boveri based his theory on the observation that some cells in early sea urchin embryos having abnormal chromosome complements wander from their usual developmental paths. His observation may have been seen by other authors at the time as support for Cohnheim's "embryonic cell rest" theory of cancer. Hansemann's contribution is seen as both the original, and the more significant of the chromosomal theories of cancer. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.