Beyond the eye: Cortical differences in primary visual processing in children with cerebral palsy.
Beyond the eye: Cortical differences in primary visual processing in children with cerebral palsy.
复制标题
眼睛之外：脑瘫儿童初级视觉处理的皮质差异。
DOI：
10.1016/j.nicl.2020.102318
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kurz,MaxJ
中科院分区：
文献类型：
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作者：
VerMaas,JacyR;Embury,ChristineM;Hoffman,RashelleM;Trevarrow,MichaelP;Wilson,TonyW;Kurz,MaxJ
尽管越来越多的临床认识到脑瘫（CP）患者的视觉障碍，很少有研究评估视觉回路的神经生理学。为此，本研究的主要目的是使用脑磁图和波束形成方法来成像由空间光栅刺激（例如视觉对比）引起的α - β和γ枕皮质振荡的相对变化，这些振荡是由CP儿童和典型发育（TD）儿童观察的。我们的研究结果表明，高对比度的视觉光栅刺激引起枕叶皮层α - β (10 - 20 Hz)活动的减少，以及低（40 - 56 Hz）和高（60 - 72 Hz）伽马振荡的增加。与TD儿童相比，CP儿童的频率特异性皮层振荡强度明显较弱，表明他们对对比刺激的加工不足。虽然CP在很大程度上被认为是一种以肌肉骨骼为中心的疾病，但我们的研究结果使越来越多的人认为，CP也可能存在突出的视觉处理缺陷。这些视觉处理缺陷可能会影响感知环境中视觉变化的能力。
Despite the growing clinical recognition of visual impairments among people with cerebral palsy (CP), very few studies have evaluated the neurophysiology of the visual circuitry. To this end, the primary aim of this investigation was to use magnetoencephalography and beamforming methods to image the relative change in the alpha–beta and gamma occipital cortical oscillations induced by a spatial grating stimulus (e.g., visual contrast) that was viewed by a cohort of children with CP and typically-developing (TD) children. Our results showed that the high-contrast, visual gratings stimuli induced a decrease in alpha–beta (10 – 20 Hz) activity, and an increase in both low (40 – 56 Hz) and high (60 – 72 Hz) gamma oscillations in the occipital cortices. Compared with the TD children, the strength of the frequency specific cortical oscillations were significantly weaker in the children with CP, suggesting that they had deficient processing of the contrast stimulus. Although CP is largely perceived as a musculoskeletal centric disorder, our results fuel the growing impression that there may also be prominent visual processing deficiencies. These visual processing deficits likely impact the ability to perceive visual changes in the environment.