Prenatal Detection of Fetal Growth Restriction in Newborns Classified as Small for Gestational Age: Correlates and Risk of Neonatal Morbidity
Prenatal Detection of Fetal Growth Restriction in Newborns Classified as Small for Gestational Age: Correlates and Risk of Neonatal Morbidity
复制标题
DOI：
10.1055/s-0033-1343771
复制
发表时间：
2014-03-01
影响因子：
2
通讯作者：
Ananth, Cande V.
中科院分区：
文献类型：
--
作者：
Chauhan, Suneet P.;Beydoun, Hind;Ananth, Cande V.
我们在四个中心检查了产前发现小于胎龄儿(SGA；出生体重和体重10%)作为宫内生长受限(IUGR)的比率，并确定了在检测到和未检测到(没有产前诊断的IUGR)之间新生儿综合发病率(CNM)和死亡率的风险。对11,487名在22周前进行超声检查的非异常单胎活产儿进行了多中心队列研究。在11487名新生儿中，8%(n=929)的SGA符合纳入标准，其中25%是产前检测到的。在产前发现为IUGR的SGA新生儿中，CNM(23.3%)高于未发现的SGA(9.7%)，但在调整混杂因素后，这一差异不再显著。在早产儿(<；37周)中，未发现的SGA在24~33周分娩的风险比[RR]10.0，95%可信区间[CI]6.3，16.1显著高于34~36周分娩的RR 3.0，95%CI 1.7，5.4。总而言之，只有四分之一的SGA出生在产前被检测为IUGR，而在早产儿SGA中，当SGA出生未被检测为IUGR时，CNM显著更高。
We examined the rate of detecting small for gestational age (SGA; birth weight < 10%) as intrauterine growth restriction (IUGR) prenatally at four centers and determined risks of composite neonatal morbidity (CNM) and mortality among detected versus undetected (no antenatal diagnosis of IUGR). A multicenter cohort study of 11,487 nonanomalous, singleton live births with sonographic exam before 22 weeks was performed. Of 11,487 births, 8% (n = 929) were SGA that met the inclusion criteria, with 25% of them being prenatally detected. The CNM among SGA births that were prenatally detected as IUGR was higher (23.3%) than undetected SGA (9.7%), but this difference was no longer significant following adjustments for confounding factors. Among preterm births (< 37 weeks), undetected SGA had significantly higher CNM (risk ratio [RR] 10.0, 95% confidence interval [CI] 6.3, 16.1) for deliveries at 24 to 33 weeks and RR 3.0, 95% CI 1.7, 5.4 for 34 to 36 weeks). In summary, only a quarter of SGA births were detected prenatally as IUGR and among preterm SGA, the CNM is significantly higher when SGA births are undetected as IUGR.