Unilateral associated laryngeal paralysis due to varicella-zoster virus: virus antibody testing and videofluoroscopic findings
Unilateral associated laryngeal paralysis due to varicella-zoster virus: virus antibody testing and videofluoroscopic findings
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DOI：
10.1017/s0022215107000898
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发表时间：
2008-02-01
影响因子：
1.7
通讯作者：
Shoji, H.
中科院分区：
文献类型：
--
作者：
Chitose, S-I;Umeno, H.;Shoji, H.
水痘带状疱疹病毒和特发性喉麻痹之间的关系进行了检查，在5例患者，使用补体结合或酶免疫试验。在所有病例中，观察到水痘带状疱疹病毒抗体血清水平的显著变化。电视透视是有用的，在评估吞咽困难的严重程度，并在作出准确的诊断，喉抬高和咽壁收缩的弱点也被观察到。在两例抗病毒治疗延迟的病例中，结果很差，酶免疫测定法发现水痘带状疱疹病毒免疫球蛋白M水平升高。因此，病情的结果可能取决于症状发作后开始抗病毒治疗的速度，以及水痘带状疱疹病毒免疫球蛋白M抗体的水平（通过酶免疫测定法测量）。我们的研究表明，水痘带状疱疹病毒应考虑在鉴别诊断的患者与特发性喉麻痹，并迅速抗病毒治疗，必要时应启动。
The relationship between varicella-zoster virus and idiopathic associated laryngeal paralysis was examined in five patients, using complement fixation or enzyme immunoassay testing. In all cases, significant changes in serum levels of varicella-zoster virus antibody were observed. Videofluoroscopy was useful in assessing the severity of the dysphagia and in making an accurate diagnosis; both laryngeal elevation and weakness of pharyngeal wall contraction were also observed. In two cases in which antiviral therapy was delayed, the outcome was poor, with increased levels of varicella-zoster virus immunoglobulin M found on enzyme immunoassay. The outcome of the condition may thus depend both on the speed of antiviral therapy commencement following onset of symptoms, and on the levels of varicella-zoster virus immunoglobulin M antibody (measured by enzyme immunoassay). Our study suggests that varicella-zoster virus should be considered in the differential diagnosis of patients with idiopathic associated laryngeal paralysis, and rapid antiviral therapy should be initiated when necessary.