Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration
Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration
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DOI：
10.1016/j.dib.2019.103950
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发表时间：
2019-06-01
期刊：
影响因子：
1.2
通讯作者：
Caprioli, Joseph
中科院分区：
文献类型：
--
作者：
Trzeciecka, Anna;Stark, David T.;Caprioli, Joseph
在成年哺乳动物中，视网膜神经节细胞（RGC）在损伤后无法再生。因此，RGC 在急性损伤和进行性退行性疾病（如青光眼）后会死亡。这可能导致永久性视力丧失，并最终失明。脂质对于细胞膜、髓鞘和细胞信号通路的发育和维持至关重要，然而，人们对其在轴突损伤和修复中的作用知之甚少。检查视神经（ON）再生过程中脂质组变化的研究可以为治疗策略提供很大的信息，但这些研究在很大程度上是缺乏的。 ON再生的实验动物模型促进了对影响RGC轴突再生的分子决定因素的探索。在这里，我们使用液相色谱-质谱法分析了 ON 挤压大鼠模型中 ON 和视网膜的脂质谱。此外，我们研究了 ON 粉碎后玻璃体内用 Zymosan（一种已知可增强 RGC 再生的酵母细胞壁衍生物）处理后脂质组的变化。该数据可在 NIH 共同基金代谢组学数据存储库和协调中心 (C) 2019 作者获取。由爱思唯尔公司出版
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RGCs die after acute injury and in progressive degenerative diseases such as glaucoma; this can lead to permanent vision loss and, eventually, blindness. Lipids are crucial for the development and maintenance of cell membranes, myelin sheaths, and cellular signaling pathways, however, little is known about their role in axon injury and repair. Studies examining changes to the lipidome during optic nerve (ON) regeneration could greatly inform treatment strategies, yet these are largely lacking. Experimental animal models of ON regeneration have facilitated the exploration of the molecular determinants that affect RGC axon regeneration. Here, we analyzed lipid profiles of the ON and retina in an ON crush rat model using liquid chromatography-mass spectrometry. Furthermore, we investigated lipidome changes after ON crush followed by intravitreal treatment with Zymosan, a yeast cell wall derivative known to enhance RGC regeneration. This data is available at the NIH Common Fund's Metabolomics Data Repository and Coordinating Center (C) 2019 The Author(s). Published by Elsevier Inc.