Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat
Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat
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DOI：
10.1016/j.pain.2006.09.016
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发表时间：
2007-04-01
期刊：
影响因子：
7.4
通讯作者：
Coudore, Francois
中科院分区：
文献类型：
--
作者：
Ling, Bing;Authier, Nicolas;Coudore, Francois
我们描述了一种由奥沙利铂重复静脉给药诱导的伤害性感觉神经病动物模型，其中治疗动物部分重现了奥沙利铂治疗患者的特征性疼痛症状。我们测试了每周两次注射1、2和4 mg/kg奥沙利铂剂量连续四周半诱导雄性Sprague-Dawley大鼠伤害性周围神经病变的能力。行为评估揭示了与机械性异常性疼痛相关的冷异常性疼痛（10 ° C）和痛觉过敏（4 ° C）症状。大鼠保持良好的一般临床状态，无运动功能障碍。选择2 mg/kg奥沙利铂剂量和冷水（10 ℃）中的尾部浸泡试验，以比较单次给药药物（如吗啡、利多卡因、卡马西平、加巴喷丁）与重复给药药物（如氯米帕明、文拉法辛、钙和镁溶液）之间的药理学敏感性。镁溶液（90 mg/kg）和文拉法辛（7.5 mg/kg）可诱导抗伤害性感受作用，而加巴喷丁（300 mg/kg）、氯丙咪嗪（2.5 mg/kg）和利多卡因（3和6 mg/kg）仅诱导所有抗异常性疼痛作用。(c)2006年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
We describe an animal model of nociceptive sensory neuropathy induced by repeat intravenous administration of oxaliplatin in which treated animals partly reproduce the characteristic pain symptoms in oxaliplatin-treated patients. We tested the ability of 1, 2 and 4 mg/kg oxaliplatin doses injected twice-weekly for four-and-a-half consecutive weeks to induce a nociceptive peripheral neuropathy in male Sprague-Dawley rats. The behavioral assessment revealed cold allodynia (10 degrees C) and hyperalgesia (4 degrees C) symptoms associated with a mechanical allodynia. The rats maintained a good general clinical status without motor dysfunction. The 2 mg/kg oxaliplatin dose and the tail-immersion test in cold water (10 degrees C) were selected to compare pharmacological sensitivity between single administered drugs as morphine, lidocaine, carbamazepine, gabapentin and repeated administration of drugs as clomipramine, venlafaxine, calcium and magnesium solutions. Magnesium Solution (90 mg/kg) and venlafaxine (7.5 mg/kg) administration induced an antinociceptive effect whereas gabapentin (300 mg/kg), clomipramine (2.5 mg/kg) and lidocaine (3 and 6 mg/kg) only induced all antiallodynic effect. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.