A Source for Feature-Based Attention in the Prefrontal Cortex.
A Source for Feature-Based Attention in the Prefrontal Cortex.
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DOI：
10.1016/j.neuron.2015.10.001
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发表时间：
2015-11-18
期刊：
影响因子：
16.2
通讯作者：
Desimone R
中科院分区：
文献类型：
--
作者：
Bichot NP;Heard MT;DeGennaro EM;Desimone R
在杂乱的场景中，我们可以使用基于特征的注意力来快速定位目标对象。为了理解特征注意力是如何被用来寻找和选择动作对象的，我们把注意力集中在前额叶皮层的腹侧前弓状区（VPA）。在视觉搜索任务中，VPA细胞选择性地响应搜索线索，在整个延迟和随后的扫视中保持其特征选择性，并在其感受野中识别搜索目标，其时间进程早于FEF或IT皮层。VPA的失活损害了动物寻找目标的能力，同时记录FEF显示，特征注意的影响被消除，而空间注意的影响在FEF中保持不变。总之，结果表明，VPA神经元计算具有所寻求特征的物体的位置，并将此信息发送到FEF，以引导眼球运动到这些相关刺激。
In cluttered scenes, we can use feature-based attention to quickly locate a target object. To understand how feature attention is used to find and select objects for action, we focused on the ventral pre-arcuate (VPA) region of prefrontal cortex. In a visual search task, VPA cells responded selectively to search cues, maintained their feature selectivity throughout the delay and subsequent saccades, and discriminated the search target in their receptive fields with a timecourse earlier than in FEF or IT cortex. Inactivation of VPA impaired the animals’ ability to find targets, and simultaneous recordings in FEF revealed that the effects of feature attention were eliminated while leaving the effects of spatial attention in FEF intact. Altogether, the results suggest that VPA neurons compute the locations of objects with the features sought and send this information to FEF to guide eye movements to those relevant stimuli.