The Pathogenesis and Natural History of Type 1 Diabetes
The Pathogenesis and Natural History of Type 1 Diabetes
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DOI：
10.1101/cshperspect.a007641
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Atkinson, Mark A.
中科院分区：
文献类型：
--
作者：
Atkinson, Mark A.
本文的目的是提供一个概述，总结了我们目前的知识状态，关于人类1型糖尿病的发病机制和自然史。这些信息作为一系列开创性的历史发现呈现给读者，当通过研究推进时，改变了我们对免疫系统，基因和环境在这种疾病形成中的作用的理解。此外，在纵向调查这三个方面发生，他们的角色内的发展1型糖尿病，从出生到症状发作及以后，进行了讨论，包括他们最有争议的元素。了解这种疾病的发病机制和自然史是试图了解导致1型糖尿病的原因以及开发预防和治疗这种疾病的方法的关键。
The purpose of this article is to provide an overview that summarizes much in the way of our current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes in humans. This information is presented to the reader as a series of seminal historical discoveries that, when advanced through research, transformed our understanding of the roles for the immune system, genes, and environment in the formation of this disease. In addition, where longitudinal investigations of these three facets occurred, their roles within the development of type 1 diabetes, from birth to symptomatic onset and beyond, are discussed, including their most controversial elements. Having an understanding of this disorder's pathogenesis and natural history is key for attempts seeking to understand the issues of what causes type 1 diabetes, as well as to develop a means to prevent and cure the disorder.