Impact of nucleos(t)ide analogues on the estimated glomerular filtration rate in patients with chronic hepatitis B: a prospective cohort study in China
Impact of nucleos(t)ide analogues on the estimated glomerular filtration rate in patients with chronic hepatitis B: a prospective cohort study in China
复制标题
核苷类似物对慢性乙型肝炎患者估计肾小球滤过率的影响：中国的一项前瞻性队列研究
DOI：
10.1111/jvh.12229
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Zhang, J. -M
中科院分区：
文献类型：
--
作者：
Qi, X.;Wang, J. -Y;Zhang, J. -M
Chronic hepatitis B therapy with nucleos(t)ide analogues, particularly tenofovir or adefovir, may affect renal function. To date, there has not been a head-to-head controlled study to assess estimated glomerular filtration rate (eGFR) fluctuations in nucleos(t)ide-treated CHB patients. We aimed to evaluate the long-term effects of nucleos(t)ide on eGFR in Chinese patients with chronic hepatitis B. This prospective cohort study included 275 patients. Patient subgroups included those treated with lamivudine (n=50), adefovir (n=60), telbivudine (n=68) and entecavir (n=61); untreated patients (n=36) served as control. After an average follow-up duration of 23months, eGFR calculated by Cockcroft-Gault and Modification of Diet in Renal Disease formulas increased by 18.35mL/min and 19.34mL/min (P
