Plasma activated Ringer’s lactate solution
Plasma activated Ringer’s lactate solution
复制标题
等离子体激活林格氏乳酸盐溶液
DOI：
10.1080/10715762.2023.2182663
复制
发表时间：
2023
影响因子：
3.3
通讯作者：
Hori Masaru
中科院分区：
文献类型：
--
作者：
Tanaka Hiromasa;Mizuno Masaaki;Ishikawa Kenji;Miron Camelia;Okazaki Yasumasa;Toyokuni Shinya;Nakamura Kae;Kajiyama Hiroaki;Hori Masaru
低温等离子体在生命科学中有着广泛的应用。等离子体活化溶液定义为用LTP辐照的溶液，并且水、培养基和林格氏溶液已经用LTP辐照以产生等离子体活化溶液。它们含有LTP、空气和溶液之间反应产生的化合物。活性氧和氮类（RONS）是等离子体活化溶液中的主要成分，并且最近的研究表明，等离子体活化的乳酸林格氏溶液（PAL）中产生等离子体活化的有机化合物。许多体外研究表明PAL具有抗肿瘤作用，生化分析揭示了PAL导致癌细胞死亡的细胞内分子机制。
Low-temperature plasma (LTP) has been widely used in life science. Plasma-activated solutions were defined as solutions irradiated with LTP, and water, medium, and Ringer’s solutions have been irradiated with LTP to produce plasma-activated solutions. They contain chemical compounds produced by reactions among LTP, air, and solutions. Reactive oxygen and nitrogen species (RONS) are major components in plasma-activated solutions and recent studies revealed that plasma-activated organic compounds are produced in plasma-activated Ringer’s lactate solution (PAL). Manyin vitroandin vivostudies demonstrated that PAL exhibits anti-tumor effects on cancers, and biochemical analyses revealed intracellular molecular mechanisms of cancer cell death by PAL.