White matter pathway supporting phonological encoding in speech production: a multi-modal imaging study of brain damage patients
White matter pathway supporting phonological encoding in speech production: a multi-modal imaging study of brain damage patients
复制标题
支持语音产生中语音编码的白质通路：脑损伤患者的多模态成像研究
DOI：
10.1007/s00429-014-0926-2
复制
发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Bi, Yanchao
中科院分区：
文献类型：
--
作者：
Han, Zaizhu;Ma, Yujun;Bi, Yanchao
在言语产生中，运动编程之前的一个重要步骤是提取和编码目标词的语音元素。语音编码由左额、颞、顶等脑区及其下的白色物质，特别是左弓状束（AF）或左上级纵束（SLF）支持。然而，目前尚不清楚AF/SLF的影响是否确实与语音编码输出有关，以及是否有其他白色物质束也有助于这一过程。我们通过研究一组69例脑损伤患者的整个大脑中所有主要白色物质束的完整性与语音编码缺陷之间的关系，全面调查了支持语音编码的解剖连接。每个白色物质束的完整性通过受损体素的百分比（结构成像）和平均各向异性分数值（扩散张量成像）来测量。在两个涉及语音编码的口语生产任务中，通过各种测量方法评估语音编码缺陷：口头图片命名中的非单词（语音）错误百分比和单词阅读的准确性，单词理解能力回归。我们发现，在结构和扩散张量成像措施的左SLF的完整性一致预测语音编码障碍的严重程度在两个语音生产任务。当通过偏相关考虑一系列潜在的混杂因素时，左SLF对语音产生的这种影响仍然显着，包括总病变体积，人口因素，语音相关灰质区域的病变，或源于语音感知或语义过程的影响。因此，我们的研究结果最终证明了中央作用的左SLF语音编码的语音生产。
In speech production, an important step before motor programming is the retrieval and encoding of the phonological elements of target words. It has been proposed that phonological encoding is supported by multiple regions in the left frontal, temporal and parietal regions and their underlying white matter, especially the left arcuate fasciculus (AF) or superior longitudinal fasciculus (SLF). It is unclear, however, whether the effects of AF/SLF are indeed related to phonological encoding for output and whether there are other white matter tracts that also contribute to this process. We comprehensively investigated the anatomical connectivity supporting phonological encoding in production by studying the relationship between the integrity of all major white matter tracts across the entire brain and phonological encoding deficits in a group of 69 patients with brain damage. The integrity of each white matter tract was measured both by the percentage of damaged voxels (structural imaging) and the mean fractional anisotropy value (diffusion tensor imaging). The phonological encoding deficits were assessed by various measures in two oral production tasks that involve phonological encoding: the percentage of nonword (phonological) errors in oral picture naming and the accuracy of word reading aloud with word comprehension ability regressed out. We found that the integrity of the left SLF in both the structural and diffusion tensor imaging measures consistently predicted the severity of phonological encoding impairment in the two phonological production tasks. Such effects of the left SLF on phonological production remained significant when a range of potential confounding factors were considered through partial correlation, including total lesion volume, demographic factors, lesions on phonological-relevant grey matter regions, or effects originating from the phonological perception or semantic processes. Our results therefore conclusively demonstrate the central role of the left SLF in phonological encoding in speech production.