An IVUS transducer for microbubble therapies.
An IVUS transducer for microbubble therapies.
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DOI：
10.1109/tuffc.2014.2929
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Hossack JA
中科院分区：
文献类型：
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作者：
Kilroy JP;Patil AV;Rychak JJ;Hossack JA
有趣的是，使用超声和治疗作用促进了使用超声处理的双重诊断和治疗作用的潜力，该角色是将药物置于该研究的目标，以设计元素和元素的元素。美国传感器IVUS的生物素化微泡位于水中，牛全血为1.5-MHz中心频率的链霉亲和素涂层的壁，峰值负压= 70 kPa脉冲，脉搏重复频率不同，而脉冲重复频率（PRF）则在超微小粘合度中均置入了prof inf fit prof inf time and fit a inf time a inf time a inf inf inf inf。常数减小（τ= 32.6 s，1 KHz与τ= 8.2 s，6 kHz），而在牛全血中，粘合剂 - 粘合剂≥8kHz的粘合剂 - 没有粘合剂。辐射力的微泡位移以及Ivus和Microbubbles的潜力提供局部药物输送。
There is interest in examining the potential of modified intravascular ultrasound (IVUS) catheters to facilitate dual diagnostic and therapeutic roles using ultrasound plus microbubbles for localized drug delivery to the vessel wall. The goal of this study was to design, prototype, and validate an IVUS transducer for microbubble-based drug delivery. A 1-D acoustic radiation force model and finite element analysis guided the design of a 1.5-MHz IVUS transducer. Using the IVUS transducer, biotinylated microbubbles were displaced in water and bovine whole blood to the streptavidin-coated wall of a flow phantom by a 1.5-MHz center frequency, peak negative pressure = 70 kPa pulse with varying pulse repetition frequency (PRF) while monitoring microbubble adhesion with ultrasound. A fit was applied to the RF data to extract a time constant (τ). As PRF was increased in water, the time constant decreased (τ = 32.6 s, 1 kHz vs. τ = 8.2 s, 6 kHz), whereas in bovine whole blood an adhesion–no adhesion transition was found for PRFs ≥ 8 kHz. Finally, a fluorophore was delivered to an ex vivo swine artery using microbubbles and the IVUS transducer, resulting in a 6.6-fold increase in fluorescence. These results indicate the importance of PRF (or duty factor) for IVUS acoustic radiation force microbubble displacement and the potential for IVUS and microbubbles to provide localized drug delivery.