[The interconnections of molecular mechanisms of hormone actions and their role in pathogenesis of obesity, insulin resistance, and diabetes mellitus].
[The interconnections of molecular mechanisms of hormone actions and their role in pathogenesis of obesity, insulin resistance, and diabetes mellitus].
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发表时间：
2008
影响因子：
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通讯作者：
I. A. Pankov;M. K. Chekhranova;S. Karpova
中科院分区：
文献类型：
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作者：
I. A. Pankov;M. K. Chekhranova;S. Karpova
论文分析了与肥胖、胰岛素抵抗和 2 型糖尿病相关的各种激素、蛋白质和其他化合物。 1）瘦素、睫状神经营养因子、脂联素、胰高血糖素样肽1、肽YY、神经调节素S以及这些激素的蛋白质受体减少食物消耗，增加能量周转，预防肥胖、胰岛素抵抗和2型糖尿病的发生。这些激素和受体作用的介质是促黑素细胞激素（MSH）、促肾上腺皮质激素释放激素（CRH）等。 2) 生长素释放肽、内源性大麻素、甘丙肽样肽及其作用介质：神经肽 Y (NPY) 和刺豚鼠基因相关蛋白 (AGRP) 增加食欲和食物消耗。过氧化物酶体增殖激活受体（PPAR）对食物摄入具有类似的作用。第一组化合物功能的激活可减少肥胖、增加能量周转、促进胰岛素作用并预防胰岛素抵抗和2型糖尿病。增加第二组物质的活性，以及减少第一组物质的活性，会产生相反的效果，促进肥胖、胰岛素抵抗和 2 型糖尿病的发展。如此多的激素作用的分子机制之间的相互联系使得研究包括糖尿病在内的各种内分泌疾病变得非常复杂。
The various hormones, proteins and other compounds related to developing obesity, insulin resistance and type 2 diabetes are analyzed in the paper. 1) Leptin, ciliary neurutrophic factor, adiponectin, glucagon-like peptide 1, peptide YY, neuromedin S, as well as the protein receptors of these hormones decrease the food consumption, increase the energy turnover, and prevent obesity, insulin resistance, and type 2 diabetes development. The mediators of these hormone and receptor actions are melanocyte stimulating hormone (MSH), corticotropin-releasing hormone (CRH), and the others. 2) Ghrelin, endogenose cannabinoides, galanin-like peptide and the mediators of their actions: neuropeptide Y (NPY) and Agouti gene related protein (AGRP) increase the appetite and food consumption. Peroxisome proliferation-activated receptor (PPAR) performs the similar action on food intake. The activation of the first group compound functioning decreases the obesity, increases the energy turnover, facilitates the insulin action and prevents the insulin resistance and type 2 diabetes. Increasing the activities of the second group, as well as, decreasing the actions of the first one of substances induce the opposite effects and facilitate obesity, insulin resistance, and type 2 diabetes developments. The interconnections of the molecular mechanisms of so many hormone actions make the very complicated tusk to study the various endocrine disorders including diabetes mellitus as well.