Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats
Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats
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DOI：
10.1016/j.drugalcdep.2008.03.014
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Daniela, Evangeline
中科院分区：
文献类型：
--
作者：
Schenk, Susan;Hely, Lincoln;Daniela, Evangeline
在动物模型中，接触自行给药的药物足以产生药物寻求行为。在许多情况下，启动注射与自我给药药物具有区别性刺激特性的药物也可能导致寻求药物，这表明暴露可能会加速复发。本研究检验了 MDMA 或可卡因启动注射恢复大鼠已熄灭的药物寻求的能力。启动可卡因注射。 (0-20.0 mg/kg) 和 MDMA (0.0-10.0 mg/kg) 可恢复可卡因和 MDMA 训练的大鼠已熄灭的吸毒状态。在另一组经过可卡因训练的大鼠中，重复暴露于 10.0 mg/kg MDMA，这是首次暴露于 MDMA。 （10.0 mg/kg，IP）未能恢复已熄灭的反应，但 MDMA 成为在重复接触下恢复已熄灭的可卡因吸食行为的有效主要手段。 MDMA 对受 MDMA 训练的大鼠的影响大于对可卡因训练的大鼠的影响，这表明 MDMA 自我给药的丰富经验可能使大鼠对此效果敏感。这些发现表明，与其他滥用药物的自我给药一样，被消灭的摇头丸自我给药可以通过接触精神兴奋剂而恢复，从而加速复发。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Exposure to self-administered drugs is sufficient to produce drug-seeking in animal models. In many cases priming injections of drugs that share discriminative stimulus properties with the self-administered drug also can lead to drug-seeking, suggesting that exposure might precipitate relapse. The present investigation examined the ability of MDMA or cocaine priming injections to reinstate extinguished drug-seeking in rats. Priming injections of cocaine. (0-20.0 mg/kg) and MDMA (0.0-10.0 mg/kg) reinstated extinguished drug-taking for both the cocaine- and MDMA-trained rats. In a separate group of cocaine-trained rats that received repeated exposure to 10.0 mg/kg MDMA, the initial exposure to MDMA. (10.0 mg/kg, IP) failed to reinstate extinguished responding but MDMA became an effective prime for reinstatement of extinguished cocaine-taking behavior with repeated exposure. Effects of MDMA in MDMA-trained rats was greater than the effect in cocaine-trained rats suggesting that extensive experience with MDMA self-administration might have sensitized rats to this effect. These findings show that extinguished MDMA self-administration, like self-administration of other drugs of abuse, can be reinstated by exposure to psychostimulants thereby precipitating relapse. (C) 2008 Elsevier Ireland Ltd. All rights reserved.