Cyclins and Breast Cancer
Cyclins and Breast Cancer
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DOI：
10.1007/bf02013639
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发表时间：
1996-04-01
影响因子：
2.5
通讯作者：
Sutherland, Robert L.
中科院分区：
文献类型：
--
作者：
Musgrove, Elizabeth A.;Hui, Rina;Sutherland, Robert L.
对细胞周期蛋白和细胞周期蛋白依赖性激酶控制细胞周期的理解的最新进展为描述类固醇增殖控制的分子机制以及激素依赖性癌症的发生和进展提供了基础。细胞周期蛋白 D1 对于乳腺癌细胞的 G(1) 进展是必要的、限速的和充分的，细胞周期蛋白 D1 表达或功能的调节是对类固醇和类固醇拮抗剂增殖调节的早期反应。大约 15% 的原发性乳腺癌中细胞周期蛋白 D1 基因被扩增，其产物在 40-50% 的原发性乳腺癌中过度表达。强有力的证据表明，细胞周期蛋白 D1 在乳腺上皮细胞的细胞周期控制中发挥着重要作用，这表明其表达失调可能对疾病进展和表型（包括对内分泌治疗的敏感性）产生影响。
Recent advances in the understanding of cell cycle control by cyclins and cyclin-dependent kinases provide a basis for delineating the molecular mechanisms of proliferation control by steroids and the development and progression of hormone-dependent cancers. Cyclin D1 is necessary, rate-limiting and sufficient for G(1) progression in breast cancer cells and regulation of cyctin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation. The cyclin D1 gene is amplified in similar to 15%, and its product overexpressed in 40-50%, of primary breast carcinomas. The strong evidence that cyclin D1 plays a major role in cell cycle control in breast epithelial cells suggests that its deregulated expression may have effects on disease progression and phenotype including sensitivity to endocrine therapies.