Progestin negatively affects hearing in aged women
Progestin negatively affects hearing in aged women
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DOI：
10.1073/pnas.0606891103
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发表时间：
2006-09-19
影响因子：
11.1
通讯作者：
Frisina, Robert D.
中科院分区：
文献类型：
--
作者：
Guimaraes, Patricia;Frisina, Susan T.;Frisina, Robert D.
女性激素对听觉系统老化的影响还不完全清楚。由于激素替代疗法（HRT）的广泛临床应用，了解HRT对感觉系统的影响至关重要。本研究回顾性分析和比较了124名绝经后妇女的听力，其中124名妇女接受HRT，雌激素和炔雌醇（E+P; n = 32），雌激素单独治疗（E; n = 30），第三个[非激素替代疗法（NHRT; n = 62）]对照组。受试者年龄为60-86岁，年龄和健康状况匹配。所有人都有相对健康的病史，没有明显的噪音暴露、中耳问题或大手术。听力测试包括纯音测听、鼓室导抗、畸变产物耳声发射（DPOAE）、瞬态耳声发射和噪声听力测试（HINT）。HINT测试在背景噪音中的言语感知，这是听力受损者的主要抱怨。与E组和对照组相比，E + P组双耳纯音听阈升高（较差）。对于DPOAE，E+P组的水平低于E组和对照组（较差），双耳差异显著。对于HINT结果，E+P组在所有背景噪声扬声器位置和安静时的言语感知比E组和对照组差。这些研究结果表明，P的存在作为HRT的一个组成部分，结果在听力较差的老年妇女服用HRT，影响外周（耳）和中枢（脑）的听觉系统，它干扰了语音在背景噪声的感知。
Female hormone influences on auditory system aging are not completely understood. Because of widespread clinical use of hormone replacement therapy (HRT), it is critical to understand HRT effects on sensory systems. The present study retrospectively analyzed and compared hearing abilities among 124 postmenopausal women taking HRT, treated with estrogen and progestin (E+P; n = 32), estrogen alone (E; n = 30), and a third [non-hormone replacement therapy (NHRT; n = 62)] control group. Subjects were 60-86 years old and were matched for age and health status. All had relatively healthy medical histories and no significant noise exposure, middle-ear problems, or major surgeries. Hearing tests included pure-tone audiometry, tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions, and the hearing-in-noise test (HINT). The HINT tests for speech perception in background noise, the major complaint of hearing-impaired persons. Pure-tone thresholds in both ears were elevated (poorer) for the E+P relative to the E and control groups, For DPOAEs, the E+P group presented with lower (worse) levels than the E and control groups, with significant differences for both ears. For the HINT results, the E+P group had poorer speech perception than the E and control groups across all background noise speaker locations and in quiet. These findings suggest that the presence of P as a component of HRT results in poorer hearing abilities in aged women taking HRT, affecting both the peripheral (ear) and central (brain) auditory systems, and it interferes with the perception of speech in background noise.