ARIC Welcomes Cancer Survivors Into Their Communities: Unraveling the Link Between Cancer and Cardiovascular Disease.
ARIC Welcomes Cancer Survivors Into Their Communities: Unraveling the Link Between Cancer and Cardiovascular Disease.
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ARIC 欢迎癌症幸存者加入他们的社区：揭示癌症与心血管疾病之间的联系。
DOI：
10.1016/j.jacc.2022.04.041
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发表时间：
2022
影响因子：
24
通讯作者：
Steingart,RichardM
中科院分区：
文献类型：
--
作者：
Yu,AnthonyF;Steingart,RichardM
由于人口老龄化，以及由于癌症早期发现和有效的癌症治疗，癌症预后的改善，全球癌症幸存者的数量正在增长。虽然与癌症相关的死亡原因一直在下降，但非癌症相关的死亡一直在上升，主要是心血管疾病(CVD)。1由于癌症幸存者，无论是年轻的还是老年的，都活得更长，他们面临着许多健康挑战，这些挑战超出了他们最初的癌症诊断。这些因素包括癌症治疗的影响(例如，与放射、手术或药物相关的直接或间接的心血管损伤)以及心理社会或生活方式的变化(例如，压力、疲劳、运动不耐受、体重增加)，这些都可能导致癌症幸存者心血管疾病风险的增加。此外，越来越多的证据表明，癌症和心血管疾病有几个共同的危险因素(如肥胖、吸烟、糖尿病和高血压)和病理机制(如炎症)，这些因素可能进一步导致癌症幸存者的不良心血管结局。2先前的研究表明，在多种癌症类型中，心血管疾病超过癌症成为主要的死亡原因。3有必要进行严格的前瞻性研究，以估计癌症幸存者的过度心血管风险，以及过度心血管风险在多大程度上可归因于共同的心血管风险因素(特别是可补救的风险因素)，以便制定和实施有效的战略，以改善癌症幸存者的长期心血管健康。
The number of cancer survivors is growing worldwide on account of the aging population and improvements in cancer outcomes attributable to earlier cancer detection and efficacious cancer treatments. Whereas cancer-related causes of death have been declining, non–cancerrelated deaths have been rising, led by cardiovascular (CV) disease (CVD). 1 Because cancer survivors, both young and old, are surviving longer, they face many health challenges that extend beyond their initial cancer diagnosis. These include effects of cancer treatment (eg, direct or indirect CV injury associated with radiation, surgery, or medications) and psychosocial or lifestyle changes (eg, stress, fatigue, exercise intolerance, weight gain), which may contribute to increased CVD risk among cancer survivors. Furthermore, there is growing evidence that cancer and CVD share several common risk factors (eg, obesity, smoking, diabetes, and hypertension) and pathologic mechanisms (eg, inflammation) that may further contribute to adverse CV outcomes among cancer survivors. 2 Prior studies have shown that CVD surpasses cancer as the leading cause of death for a wide range of cancer types. 3 There is a significant need for rigorous prospective studies to estimate the excess CVD risk of cancer survivors and the degree to which excess CVD risk can be attributed to shared CV risk factors (particularly remediable risk factors) so that effective strategies to improve long-term CV health can be developed and implemented among cancer survivors.