The role of Hippo signal pathway in breast cancer metastasis.
The role of Hippo signal pathway in breast cancer metastasis.
复制标题
Hippo信号通路在乳腺癌转移中的作用
DOI：
10.2147/ott.s157058
复制
发表时间：
2018
影响因子：
4
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Wei C;Wang Y;Li X
河马信号通路是一种新的高度保守的哺乳动物信号通路。HIPPO途径核心成分的突变和表达改变促进了乳腺癌细胞的迁移、侵袭、恶性和化疗耐药。在肿瘤转移过程中，肿瘤细胞必须脱离原发肿瘤，侵袭周围组织，进入外来微环境并存活。乳腺癌的转移潜能与个体患者的基因特征密切相关。然而，调控HIPPO通路在乳腺癌转移中的确切分子机制尚未完全阐明。本文讨论了河马信号通路的功能和调控，重点讨论了它在乳腺癌转移中的作用。
The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.