Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson's Disease
Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson's Disease
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中脑血管周围空间扩张可能反映帕金森病中的多巴胺神经元变性
DOI：
10.3389/fnagi.2020.00161
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发表时间：
2020-06-05
影响因子：
4.8
通讯作者：
Huang, Peiyu
中科院分区：
文献类型：
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作者：
Li, Yanxuan;Zhu, Zili;Huang, Peiyu
背景：α-突触核蛋白的产生和清除之间的不平衡及其随后的积累在帕金森病（PD）的发病机制中起着关键作用。α-突触核蛋白清除率的降低可能部分归因于间质液受损，这可以通过血管周围间隙（dPVS）扩张的程度来反映。我们研究了dPVS和多巴胺神经元变性之间的关联。方法：我们从帕金森进展标志物倡议（PPMI）数据库中筛选了71名健康对照（HC）和88名患者。在轴向T2加权图像上评价不同脑区的dPVS，并使用多巴胺转运蛋白（DAT）成像数据来阐明多巴胺能神经元变性的程度。根据黑质（substantia nigra，SN）是否存在dPVS，将PD患者进一步分为SN + PD组和SN - PD组。比较PD和HC患者的DAT摄取值和临床量表，并与dPVS评分进行比较。我们还研究了基线dPVS评分和纵向DAT变化之间的相关性。结果：PD患者SN和基底节（BG）dPVS明显多于HC。相对于那些没有SN dPVS的PD患者，SN区dPVS的PD患者在脑脊液中表现出更高的tau蛋白表达（P= 0.038）和DAT结合降低的趋势（P= 0.086）。未发现dPVS评分与DAT摄取值或dPVS评分与DAT纵向变化之间存在相关性。结论：PD患者黑质dPVS可反映多巴胺能神经元的变性。
Background:The imbalance between the production and clearance of alpha-synuclein and its consequent accumulation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). The diminished clearance of alpha-synuclein may be partly attributable to impaired interstitial fluid, which can be reflected by the extent of dilated perivascular space (dPVS). We studied the association between dPVS and dopamine neuronal degeneration. Method:We screened 71 healthy controls (HCs) and 88 patients from the Parkinson Progression Markers Initiative (PPMI) database. The dPVS was evaluated in different brain regions on axial T2-weighted images, and dopamine transporter (DAT) imaging data was used to elucidate the extent of dopaminergic neuronal degeneration. Patients with PD were further divided into two groups (SN + PD and SN - PD groups) according to whether dPVS was observed in the substantia nigra (SN). DAT uptake values and clinical scales were compared between the patients with PD and HCs and against dPVS scores. We also investigated the correlation between baseline dPVS scores and longitudinal DAT changes. Results:Relative to the HCs, patients with PD had more dPVS in the SN and basal ganglia (BG). PD patients with dPVS in the SN region exhibited greater expression of tau protein in cerebrospinal fluid (P= 0.038) and a trend towards decreased DAT binding (P= 0.086) relative to those without SN dPVS. No correlations were found between dPVS scores and DAT uptake values or between dPVS scores and longitudinal DAT changes. Conclusion:The dPVS in the SN of patients with PD may reflect the degeneration of dopaminergic neurons.