The adaptive pattern of the auditory N1 peak revealed by standardized low-resolution brain electromagnetic tomography.
The adaptive pattern of the auditory N1 peak revealed by standardized low-resolution brain electromagnetic tomography.
复制标题
标准化低分辨率脑电磁断层扫描揭示了听觉 N1 峰值的自适应模式。
DOI：
10.1016/j.brainres.2011.05.036
复制
发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
Fu,Qian-Jie
中科院分区：
文献类型：
--
作者：
Zhang,Fawen;Deshpande,Aniruddha;Benson,Chelsea;Smith,Mathew;Eliassen,James;Fu,Qian-Jie
刺激重复后，后期听觉诱发电位（LAEP） N1峰幅度减小，表现出适应模式。本研究利用标准低分辨率电磁断层扫描（sLORETA）探索了N1自适应模式背后的功能神经基质。14名年轻的听力正常（NH）听众参加了这项研究。在10组的列车中，通过插入式耳机双耳呈现音调爆发（80 dB SPL）；刺激间间隔为0.7 s，训练间间隔为15 s。对第一、第二和第十次刺激（S1、s2和S10）在对应于N1波形子分量潜伏期范围（70 - 100ms、100-130 ms和130-160 ms）的3个不同时间范围内诱发的N1进行电流源密度分析。结果表明，s1激活了不同皮质叶的广泛区域，s2和S10的激活范围要小得多。LAEP波形和sLORETA在s1和S2之间存在差异，而S2和S10之间无差异。s1和s2的sLORETA对比图显示，在70-100 ms时激活位于顶叶，在100-130 ms时激活位于额叶和边缘叶，在130-160 ms时激活位于额叶。这些sLORETA比较结果表明，顶叶-额叶网络可能通过过滤掉重复和不相关的刺激，帮助大脑对新刺激敏感。这项研究表明，sLORETA可能有助于识别头皮记录事件相关电位的产生源，并检查这些产生源的生理特征。这项技术对于无法用功能性磁共振成像或脑磁图检查的个体（例如，人工耳蜗使用者）的皮质源定位特别有用。
The N1 peak in the late auditory evoked potential (LAEP) decreases in amplitude following stimulus repetition, displaying an adaptive pattern. The present study explored the functional neural substrates that may underlie the N1 adaptive pattern using standardized Low Resolution Electromagnetic Tomography (sLORETA). Fourteen young normal hearing (NH) listeners participated in the study. Tone bursts (80 dB SPL) were binaurally presented via insert earphones in trains of 10; the inter-stimulus interval was 0.7 s and the inter-train interval was 15 s. Current source density analysis was performed for the N1 evoked by the 1st, 2nd and 10th stimuli (S1, S2and S10) at 3 different timeframes that corresponded to the latency ranges of the N1 waveform subcomponents (70–100, 100–130 and 130–160 ms). The data showed that S1activated broad regions in different cortical lobes and the activation was much smaller for S2and S10. Response differences in the LAEP waveform and sLORETA were observed between S1and S2, but not between the S2and S10. The sLORETA comparison map between S1and S2responses showed that the activation was located in the parietal lobe for the 70–100 ms timeframe, the frontal and limbic lobes for the 100–130 ms timeframe, and the frontal lobe for the 130–160 ms timeframe. These sLORETA comparison results suggest a parieto-frontal network that might help to sensitize the brain to novel stimuli by filtering out repetitive and irrelevant stimuli. This study demonstrates that sLORETA may be useful for identifying generators of scalp-recorded event related potentials and for examining the physiological features of these generators. This technique could be especially useful for cortical source localization in individuals who cannot be examined with functional magnetic resonance imaging or magnetoencephalography (e.g., cochlear implant users).