Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder
Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder
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DOI：
10.1111/acps.12478
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发表时间：
2016-03-01
影响因子：
6.7
通讯作者：
Bellivier, F.
中科院分区：
文献类型：
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作者：
Golmard, J. -L.;Scott, J.;Bellivier, F.
提示双相I型障碍（BP-I）的发病年龄（AAO）呈下降趋势。我们测试了使用混合物analysis.MethodA的3896 BP-I病例的临床样本AAO的出生队列效果进行了分析，使用两种方法：（i）在未截断AAO出生年份分布的子样本中（n=1865），我们比较了1960年和>1960年出生的患者中观察到的AAO的最佳拟合模型，（ii）控制潜在的混杂因素，出生于1960年和>1960年的两个独立的子样本在访谈时年龄匹配（n=250），并进行了进一步的混合分析。ResultsThe两种方法表明，在早期AAO类别的病例比例在>1960年出生的病例中显著更大;> 1960年出生的早发性BP-Ⅰ型患者躁狂发作率也较高。结论近期出生人群中BP-Ⅰ型AAO的降低与早发性亚组的比例增加有关;而不是每个假定亚组的平均AAO降低。这可能表明暴露于躁狂风险因素的时间变化。
ObjectiveIt is suggested that age at onset (AAO) of bipolar I disorder (BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis.MethodA clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAOxbirth year distribution (n=1865), we compared the best-fitting model for the observed AAO in patients born 1960 and >1960, (ii) to control for potential confounders, two separate subsamples born 1960 and >1960 were matched for age at interview (n=250), and a further admixture analysis was undertaken.ResultsThe two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP-I cases born >1960.ConclusionThe decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania.