TN/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
TN/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
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DOI：
10.1016/s1074-7613(03)00171-7
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发表时间：
2003-07-01
期刊：
影响因子：
32.4
通讯作者：
Pamer, EG
中科院分区：
文献类型：
--
作者：
Serbina, NV;Salazar-Mather, TP;Pamer, EG
树突状细胞（dc）向T细胞提供微生物抗原，并提供调节T细胞分化的炎症信号。虽然dc在适应性免疫中的作用已经确立，但它们在先天免疫防御中的作用还不太明确。我们已经在单核细胞增生李斯特菌感染小鼠的脾脏中发现了一个TNF/ inos生成(Tip)-DC亚群，而在ccr2缺陷小鼠中则不存在。tip - dc的缺失导致严重的TNF和iNOS缺乏，无法清除原发性细菌感染。CD8和CD4 T细胞对单核增生乳杆菌抗原的反应在ccr2缺陷小鼠中得以保留，这表明tip - dc对T细胞启动不是必需的。在单核增生乳杆菌感染过程中，tip - dc作为TNF和iNOS的主要来源，协调和介导了针对这种细胞内细菌病原体的先天免疫防御。
Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen.