A COMPARISON OF THE BEHAVIORAL-EFFECTS OF PROTEO-N AND DEUTERO-N, N-DIMETHYLTRYPTAMINE
A COMPARISON OF THE BEHAVIORAL-EFFECTS OF PROTEO-N AND DEUTERO-N, N-DIMETHYLTRYPTAMINE
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DOI：
10.1016/0091-3057(82)90240-4
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
LIU, WF
中科院分区：
文献类型：
--
作者：
BEATON, JM;BARKER, SA;LIU, WF
采用强化饮食方案，观察了2.5 mg/kg和5.0 mg/kg剂量的N，N-二甲基色胺(DMT)和α、α、β、β-四氢-N，N-二甲基色胺(D4DMT)对大鼠行为学的影响。与DMT相比，D4DMT产生的行为干扰明显更大，作用持续时间更长，发病时间更短。这种增强，显然是由于动力学同位素效应，表明DMT被α-位的脱氨作用显著代谢和失活。
The behavioral effects of N,N-dimethyltryptamine (DMT) and .alpha.,.alpha.,.beta.,.beta.-tetradeutero-N,N-dimethyltryptamine (D4DMT) at dose levels of 2.5 and 5.0 mg/kg were examined in rats on a food reinforced schedule. The D4DMT produced a significantly greater disruption of behavior, had a longer duration of action and a shorter time to onset than DMT. This potentiation, apparently due to the kinetic isotope effect, suggests that DMT is significantly metabolized and deactivated by deamination at the .alpha.-position.