Necrotizing Enterocolitis-150 Years of Fruitless Search for the Cause
Necrotizing Enterocolitis-150 Years of Fruitless Search for the Cause
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DOI：
10.1159/000215590
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发表时间：
2009-01-01
期刊：
影响因子：
2.5
通讯作者：
Obladen, Michael
中科院分区：
文献类型：
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作者：
Obladen, Michael
坏死性小肠结肠炎（NEC）并不是一种新的疾病，但自从特殊护理单位开始收容早产儿以来就有报道。在巴黎[Billard，1828]和维也纳[Bednar，1850]的弃婴医院中观察到了这种病毒，由于它是聚集性发生的，因此在苏黎世[Willi，1944]和柏林[Ylppo，1931]的婴儿医院中被认为是医院感染。施密特和梅瑟瑟在1952年完成了临床和病理解剖特征的鉴定。肠系膜灌注不足是一个主要病因的假说尚未得到证实，这一假说来自动物模型和足月儿类似的穿孔性疾病。尽管NEC和梭菌感染之间有相似之处，但很少有研究采用厌氧培养技术。其发病机制尚不清楚，其与相关疾病的区别不确定。除非更好地了解这种疾病，否则预防NEC的策略不太可能成功。版权所有（C）2009 S. Karger AG，巴塞尔
Necrotizing enterocolitis (NEC) is not a new disease but one that has been reported since special care units began to house preterm infants. It was observed in foundling hospitals in Paris [Billard, 1828] and Vienna [Bednar, 1850] and, as it occurred in clusters, was regarded as a nosocomial infection in the infant hospitals of Zurich [Willi, 1944] and Berlin [Ylppo, 1931]. Clinical and patho-anatomic characterization was achieved by Schmidt and Quaiser in 1952. The unproven hypothesis of mesenteric hypoperfusion as a major etiological factor arose from animal models and analogous perforating disorders in term infants. Despite similarities between NEC and clostridial infections, few studies employed anaerobic culture techniques. The pathogenesis remains unclear and its distinction from related disorders uncertain. It is unlikely that strategies to prevent NEC will be successful unless the disease is better understood. Copyright (C) 2009 S. Karger AG, Basel