Nore1a drives Ras to flick the P53 senescence switch.
Nore1a drives Ras to flick the P53 senescence switch.
复制标题
Nore1a驱动Ras打开P53衰老开关。
DOI：
10.1080/23723556.2015.1055050
复制
发表时间：
2016
影响因子：
2.1
通讯作者：
Clark,GeoffreyJ
中科院分区：
文献类型：
--
作者：
Donninger,Howard;Clark,GeoffreyJ
RAS 诱导的衰老是一种保护机制，可避免由于异常的有丝分裂信号而导致细胞生长不受限制；然而，RAS 诱导衰老的确切机制尚不清楚。我们最近发现了一条通过 NORE1A 和 HIPK2 连接 RAS 与 p53 的新途径，从机制上解释了 Ras 如何诱导衰老。
RAS-induced senescence is a protective mechanism to avoid unrestricted cell growth due to aberrant mitogenic signals; however, the exact mechanism by which RAS induces senescence is not known. We recently identified a novel pathway linking RAS to p53 via NORE1A and HIPK2 that mechanistically explains how Ras induces senescence.