When it is better to regress: dynamics of vascular pruning.
When it is better to regress: dynamics of vascular pruning.
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DOI：
10.1371/journal.pbio.1002148
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发表时间：
2015-05
期刊：
影响因子：
9.8
通讯作者：
Simons M
中科院分区：
文献类型：
--
作者：
Ricard N;Simons M
脊椎动物的血管网对组织的生存至关重要。完全功能的脉管系统的建立是复杂的，并且需要许多步骤，包括血管发生和血管生成，随后分化成专门的血管组织（即，动脉、静脉和血管）和器官特异性分化。然而，这个过程中同样重要的一步是修剪过多的血管。最近的研究表明，修剪对于血液有效灌注到组织中至关重要。尽管它的意义，血管修剪是最不了解的过程中维管分化和发展。最近发表的两篇PLOS生物学论文提供了关于血管退化的细胞动力学的重要新信息。血管修剪是形成和维持有效血管网络的重要一步;这篇文章评估了PLOS Biology最近的两篇论文，探讨了血管退化的分子机制。
Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression. Blood vessel pruning is an important step in formation and maintenance of effective vascular networks; this Primer assesses two recent papers in PLOS Biology that explore molecular mechanisms of blood vessel regression.
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影响因子：
11.8
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通讯作者：
Simons M