COVID-19 in lung transplant patients: A case series
COVID-19 in lung transplant patients: A case series
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DOI：
10.1111/ajt.16212
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发表时间：
2020-08-29
影响因子：
8.8
通讯作者：
Vos, Robin
中科院分区：
文献类型：
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作者：
Verleden, Geert M.;Godinas, Laurent;Vos, Robin
实体器官移植后感染2019冠状病毒病的多篇病例报告和小病例系列已发表；然而，迄今为止，关于肺移植患者感染 2019 冠状病毒病的数据有限。在目前的单中心病例系列中，我们讨论了 10 名患有严重急性呼吸综合征冠状病毒 2 感染的肺移植患者，其中 8 名患者通过鼻咽拭子检查，2 名患者接受支气管肺泡灌洗诊断。10 名患者中有 8 名需要入院，其中 1 名患者在重症监护室。两周后，他因多器官衰竭去世。其余九名患者康复。所有患者均停止使用细胞周期抑制剂，而钙调神经磷酸酶抑制剂和皮质类固醇继续以相同剂量使用，结果令人满意。
Several case reports and small case series have been published on coronavirus disease 2019 infection after solid organ transplantation; however, thus far there are limited data on coronavirus disease 2019 infections in lung transplant patients. In the present single-center case series we discuss 10 lung transplant patients with a documented severe acute respiratory syndrome coronavirus 2 infection, diagnosed with nasopharyngeal swab in 8 and bronchoalveolar lavage in 2. Eight of 10 patients needed hospital admission, of whom 1 was in the intensive care unit. He died after 2 weeks from multiple organ failure. The remaining nine patients recovered. Cell cycle inhibitors were withheld in all patients, whereas the calcineurin inhibitor and corticosteroids were continued at the same dose, with an acceptable outcome.